Successful Use of Intraperitoneal Daptomycin in the Treatment of Vancomycin-Resistant Enterococcus Peritonitis

Sarah Huen, Isaac Hall, Jeffrey Topal, Rex L. Mahnensmith, Ursula C. Brewster, Ali K. Abu-Alfa

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Peritoneal dialysis-associated peritonitis from such resistant organisms as vancomycin-resistant enterococci increasingly is occurring and is challenging to treat. We describe 2 cases of vancomycin-resistant entercoccus peritonitis successfully treated with intraperitoneal daptomycin. Both patients were on automated peritoneal dialysis therapy with culture-positive vancomycin-resistant Enterococcus faecium peritonitis and were treated with 10 to 14 days of intraperitoneal daptomycin given every 4 hours through manual peritoneal dialysate exchanges. Despite the known degradation in dextrose solutions, intraperitoneal daptomycin was effective in clearing both infections. Neither patient experienced a relapse or repeated peritonitis. Additional studies of dosing and pharmacokinetics of intraperitoneal daptomycin in the treatment of patients with vancomycin-resistant enterococcus peritonitis are needed.

Original languageEnglish (US)
Pages (from-to)538-541
Number of pages4
JournalAmerican Journal of Kidney Diseases
Volume54
Issue number3
DOIs
StatePublished - Sep 1 2009

Fingerprint

Daptomycin
Peritonitis
Peritoneal Dialysis
Therapeutics
Enterococcus faecium
Dialysis Solutions
Vancomycin
Pharmacokinetics
Vancomycin-Resistant Enterococci
Glucose
Recurrence
Infection

Keywords

  • daptomycin
  • Peritoneal dialysis
  • peritonitis
  • vancomycin-resistant enterococcus

ASJC Scopus subject areas

  • Nephrology

Cite this

Successful Use of Intraperitoneal Daptomycin in the Treatment of Vancomycin-Resistant Enterococcus Peritonitis. / Huen, Sarah; Hall, Isaac; Topal, Jeffrey; Mahnensmith, Rex L.; Brewster, Ursula C.; Abu-Alfa, Ali K.

In: American Journal of Kidney Diseases, Vol. 54, No. 3, 01.09.2009, p. 538-541.

Research output: Contribution to journalArticle

Huen, Sarah ; Hall, Isaac ; Topal, Jeffrey ; Mahnensmith, Rex L. ; Brewster, Ursula C. ; Abu-Alfa, Ali K. / Successful Use of Intraperitoneal Daptomycin in the Treatment of Vancomycin-Resistant Enterococcus Peritonitis. In: American Journal of Kidney Diseases. 2009 ; Vol. 54, No. 3. pp. 538-541.
@article{08bfd51437134de78eb40aced75a3264,
title = "Successful Use of Intraperitoneal Daptomycin in the Treatment of Vancomycin-Resistant Enterococcus Peritonitis",
abstract = "Peritoneal dialysis-associated peritonitis from such resistant organisms as vancomycin-resistant enterococci increasingly is occurring and is challenging to treat. We describe 2 cases of vancomycin-resistant entercoccus peritonitis successfully treated with intraperitoneal daptomycin. Both patients were on automated peritoneal dialysis therapy with culture-positive vancomycin-resistant Enterococcus faecium peritonitis and were treated with 10 to 14 days of intraperitoneal daptomycin given every 4 hours through manual peritoneal dialysate exchanges. Despite the known degradation in dextrose solutions, intraperitoneal daptomycin was effective in clearing both infections. Neither patient experienced a relapse or repeated peritonitis. Additional studies of dosing and pharmacokinetics of intraperitoneal daptomycin in the treatment of patients with vancomycin-resistant enterococcus peritonitis are needed.",
keywords = "daptomycin, Peritoneal dialysis, peritonitis, vancomycin-resistant enterococcus",
author = "Sarah Huen and Isaac Hall and Jeffrey Topal and Mahnensmith, {Rex L.} and Brewster, {Ursula C.} and Abu-Alfa, {Ali K.}",
year = "2009",
month = "9",
day = "1",
doi = "10.1053/j.ajkd.2008.12.017",
language = "English (US)",
volume = "54",
pages = "538--541",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Successful Use of Intraperitoneal Daptomycin in the Treatment of Vancomycin-Resistant Enterococcus Peritonitis

AU - Huen, Sarah

AU - Hall, Isaac

AU - Topal, Jeffrey

AU - Mahnensmith, Rex L.

AU - Brewster, Ursula C.

AU - Abu-Alfa, Ali K.

PY - 2009/9/1

Y1 - 2009/9/1

N2 - Peritoneal dialysis-associated peritonitis from such resistant organisms as vancomycin-resistant enterococci increasingly is occurring and is challenging to treat. We describe 2 cases of vancomycin-resistant entercoccus peritonitis successfully treated with intraperitoneal daptomycin. Both patients were on automated peritoneal dialysis therapy with culture-positive vancomycin-resistant Enterococcus faecium peritonitis and were treated with 10 to 14 days of intraperitoneal daptomycin given every 4 hours through manual peritoneal dialysate exchanges. Despite the known degradation in dextrose solutions, intraperitoneal daptomycin was effective in clearing both infections. Neither patient experienced a relapse or repeated peritonitis. Additional studies of dosing and pharmacokinetics of intraperitoneal daptomycin in the treatment of patients with vancomycin-resistant enterococcus peritonitis are needed.

AB - Peritoneal dialysis-associated peritonitis from such resistant organisms as vancomycin-resistant enterococci increasingly is occurring and is challenging to treat. We describe 2 cases of vancomycin-resistant entercoccus peritonitis successfully treated with intraperitoneal daptomycin. Both patients were on automated peritoneal dialysis therapy with culture-positive vancomycin-resistant Enterococcus faecium peritonitis and were treated with 10 to 14 days of intraperitoneal daptomycin given every 4 hours through manual peritoneal dialysate exchanges. Despite the known degradation in dextrose solutions, intraperitoneal daptomycin was effective in clearing both infections. Neither patient experienced a relapse or repeated peritonitis. Additional studies of dosing and pharmacokinetics of intraperitoneal daptomycin in the treatment of patients with vancomycin-resistant enterococcus peritonitis are needed.

KW - daptomycin

KW - Peritoneal dialysis

KW - peritonitis

KW - vancomycin-resistant enterococcus

UR - http://www.scopus.com/inward/record.url?scp=68849118678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68849118678&partnerID=8YFLogxK

U2 - 10.1053/j.ajkd.2008.12.017

DO - 10.1053/j.ajkd.2008.12.017

M3 - Article

C2 - 19237231

AN - SCOPUS:68849118678

VL - 54

SP - 538

EP - 541

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 3

ER -