Successful Use of Intraperitoneal Daptomycin in the Treatment of Vancomycin-Resistant Enterococcus Peritonitis

Sarah Huen, Isaac Hall, Jeffrey Topal, Rex L. Mahnensmith, Ursula C. Brewster, Ali K. Abu-Alfa

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Peritoneal dialysis-associated peritonitis from such resistant organisms as vancomycin-resistant enterococci increasingly is occurring and is challenging to treat. We describe 2 cases of vancomycin-resistant entercoccus peritonitis successfully treated with intraperitoneal daptomycin. Both patients were on automated peritoneal dialysis therapy with culture-positive vancomycin-resistant Enterococcus faecium peritonitis and were treated with 10 to 14 days of intraperitoneal daptomycin given every 4 hours through manual peritoneal dialysate exchanges. Despite the known degradation in dextrose solutions, intraperitoneal daptomycin was effective in clearing both infections. Neither patient experienced a relapse or repeated peritonitis. Additional studies of dosing and pharmacokinetics of intraperitoneal daptomycin in the treatment of patients with vancomycin-resistant enterococcus peritonitis are needed.

Original languageEnglish (US)
Pages (from-to)538-541
Number of pages4
JournalAmerican Journal of Kidney Diseases
Volume54
Issue number3
DOIs
StatePublished - Sep 1 2009

Keywords

  • Peritoneal dialysis
  • daptomycin
  • peritonitis
  • vancomycin-resistant enterococcus

ASJC Scopus subject areas

  • Nephrology

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