Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2

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Abstract

Fumarate hydratase (FH) is a tumor suppressor, but how it acts is unclear. Two reports in this issue of Cancer Cell reveal that FH deficiency leads to succination of Keap1, stabilization of Nrf2, and induction of stress-response genes including HMOX1, which is important for the survival of FH-deficient cells.

Original languageEnglish (US)
Pages (from-to)418-420
Number of pages3
JournalCancer Cell
Volume20
Issue number4
DOIs
Publication statusPublished - Oct 18 2011

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ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

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