Sudden unexpected death in epilepsy

Maromi Nei, Ryan Hays

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Sudden unexpected death in epilepsy (SUDEP) is a significant cause of death for people with epilepsy. Recent research suggests that multiple factors may contribute and that both cardiac and respiratory mechanisms are involved. Both human and animal data suggest that specific genetic factors might play a role in some cases. Recent animal data suggest that serotonin might affect respiratory mechanisms and may be involved. Both cardiac and respiratory abnormalities are more likely with generalized tonic-clonic seizures. Uncontrolled epilepsy, particularly with generalized tonic-clonic seizures, appears to be the most highly associated modifiable risk factor for SUDEP.

Original languageEnglish (US)
Pages (from-to)319-326
Number of pages8
JournalCurrent Neurology and Neuroscience Reports
Volume10
Issue number4
DOIs
StatePublished - Jul 2010

Fingerprint

Sudden Death
Epilepsy
Seizures
Cause of Death
Serotonin
Research

Keywords

  • Cardiac
  • Epidemiology
  • Epilepsy
  • Mortality
  • Pulmonary
  • Seizure
  • Sudden death
  • SUDEP

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Sudden unexpected death in epilepsy. / Nei, Maromi; Hays, Ryan.

In: Current Neurology and Neuroscience Reports, Vol. 10, No. 4, 07.2010, p. 319-326.

Research output: Contribution to journalArticle

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