1H and 15N assignments and secondary structure of the Src SH3 domain

Hongtao Yu, Michael K. Rosen, Stuart L. Schreiber

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The 1H and 15N sequential assignments of the Src SH3 domain have been determined through a combination of 2D and 3D Nuclear Magnetic Resonance (NMR) methods. The secondary structure of the protein has been identified based on long-range NOE patterns. The SH3 domain of Src consists largely of six β-strands that form two anti-parallel β-sheets.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalFEBS Letters
Volume324
Issue number1
DOIs
StatePublished - Jun 7 1993

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src Homology Domains
Nuclear magnetic resonance
Secondary Protein Structure
Proteins
Magnetic Resonance Spectroscopy

Keywords

  • Nuclear magnetic resonance
  • Secondary structure
  • SH3 domain
  • Src

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

1H and 15N assignments and secondary structure of the Src SH3 domain. / Yu, Hongtao; Rosen, Michael K.; Schreiber, Stuart L.

In: FEBS Letters, Vol. 324, No. 1, 07.06.1993, p. 87-92.

Research output: Contribution to journalArticle

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