Abstract
Adherence and growth rates of human aortic endothelial cells (HAEC) on plasma polymerized poly(vinylacetic acid) films were measured as functions of the surface density of ACOOH groups and plasma deposited film thickness. Pulsed plasma polymerization was employed to produce films containing 3.6 to 9% ACOOH groups, expressed as a percent of total carbon content. Endothelial cells exhibited increased cell adherence and proliferation with increasing ACOOH surface densities. Additionally, and unexpectedly, cell growth was also dependent on the film thicknesses, which ranged from 25 to 200 nm. The results indicate that optimization of the functional group surface density and film thickness could produce significant enhancements in initial adhesion and subsequent growth of the HAEC cells.
Original language | English (US) |
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Pages (from-to) | 640-648 |
Number of pages | 9 |
Journal | Journal of Biomedical Materials Research - Part A |
Volume | 94 |
Issue number | 2 |
DOIs | |
State | Published - Aug 2010 |
Keywords
- Carboxylic acids
- Endothelial cells
- Film chemistry
- Film thickness
- Plasma polymerization
- Surface modification
ASJC Scopus subject areas
- Ceramics and Composites
- Biomaterials
- Biomedical Engineering
- Metals and Alloys