Surface chemistry and polymer film thickness effects on endothelial cell adhesion and proliferation

Dhiman Bhattacharyya, Hao Xu, Rajendra R. Deshmukh, Richard B. Timmons, Kytai T. Nguyen

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Adherence and growth rates of human aortic endothelial cells (HAEC) on plasma polymerized poly(vinylacetic acid) films were measured as functions of the surface density of ACOOH groups and plasma deposited film thickness. Pulsed plasma polymerization was employed to produce films containing 3.6 to 9% ACOOH groups, expressed as a percent of total carbon content. Endothelial cells exhibited increased cell adherence and proliferation with increasing ACOOH surface densities. Additionally, and unexpectedly, cell growth was also dependent on the film thicknesses, which ranged from 25 to 200 nm. The results indicate that optimization of the functional group surface density and film thickness could produce significant enhancements in initial adhesion and subsequent growth of the HAEC cells.

Original languageEnglish (US)
Pages (from-to)640-648
Number of pages9
JournalJournal of Biomedical Materials Research - Part A
Volume94
Issue number2
DOIs
StatePublished - Aug 2010

Keywords

  • Carboxylic acids
  • Endothelial cells
  • Film chemistry
  • Film thickness
  • Plasma polymerization
  • Surface modification

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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