Surface expression and synthesis of I-A and I-E/C encoded molecules by B lymphocytes and Ig-secreting cells

E. S. Vitetta, R. G. Cook

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6 Scopus citations


Splenocytes from recombinant mice were radiolabeled before or after deletion of subpopulations by cytotoxic anterisera (+C) directed against I-A, I-E/C, IgM, or Ig. Examination of the lysates of the surviving cells by immunoprecipitation demonstrated that 1) virtually all I-A and I-E/C molecules are co-expressed and synthesized by Ig+, IgM+ lymphocytes, 2) I-A, I-E/C, and IgM molecules are present on many of the cells secreting IgM and IgG, and 3) populations of bearing or Ig secreting cells that lack detectable I-A and I-E/C antigens can be identified in spleen cell populations. The co expression of I-A and I-E/C on most cells of the B cell lineage is discussed in terms of our present concepts of Ir gene control of immune responses.

Original languageEnglish (US)
Pages (from-to)2122-2130
Number of pages9
JournalJournal of Immunology
Issue number5
StatePublished - Jan 1 1979


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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