Surface expression and synthesis of I-A and I-E/C encoded molecules by B lymphocytes and Ig-secreting cells

E. S. Vitetta, R. G. Cook

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Splenocytes from recombinant mice were radiolabeled before or after deletion of subpopulations by cytotoxic anterisera (+C) directed against I-A, I-E/C, IgM, or Ig. Examination of the lysates of the surviving cells by immunoprecipitation demonstrated that 1) virtually all I-A and I-E/C molecules are co-expressed and synthesized by Ig+, IgM+ lymphocytes, 2) I-A, I-E/C, and IgM molecules are present on many of the cells secreting IgM and IgG, and 3) populations of bearing or Ig secreting cells that lack detectable I-A and I-E/C antigens can be identified in spleen cell populations. The co expression of I-A and I-E/C on most cells of the B cell lineage is discussed in terms of our present concepts of Ir gene control of immune responses.

Original languageEnglish (US)
Pages (from-to)2122-2130
Number of pages9
JournalJournal of Immunology
Volume122
Issue number5
StatePublished - 1979

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B-Lymphocytes
Immunoglobulin M
Cell Lineage
Immunoprecipitation
Population
Spleen
Immunoglobulin G
Lymphocytes
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Surface expression and synthesis of I-A and I-E/C encoded molecules by B lymphocytes and Ig-secreting cells. / Vitetta, E. S.; Cook, R. G.

In: Journal of Immunology, Vol. 122, No. 5, 1979, p. 2122-2130.

Research output: Contribution to journalArticle

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