Sweat gland adenomas: Immunohistochemical study with emphasis on myoepithelial differentiation

E. L. Wiley, S. Milchgrub, R. G. Freeman, E. S. Kim

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Thirty-one dermal appendage tumors of sweat gland differentiation including 7 spiradenomas (SPA), 8 cylindromas (CYL), 8 acrospiromas (ACS), and 8 chondroid syringomas (CS) were analyzed using antibodies to epithelial membrane antigen (EMA), cytokeratin (AE1, AE3, CAM 5.2, 34BE12), S-100 protein, actin (ACT), and desmin (DES) to characterize the immunocytochemical profile of benign sweat gland tumors. Cytokeratin expression was variable; AE1, 34BE12, AE3, and CAM 5.2 were present in 31, 24, 23, and 22 tumors respectively; 29 tumors contained EMA. Seventeen tumors, (6 SPA, 8 CYL, 2 ACS, 1 CS) stained with antibody to alpha smooth muscle actin, and 26 (7 SPA, 7 CYL, 4 ACS, 8 CS) expressed S-100 protein. Although some prior studies had reported actin filaments on electron microscopy in both spiradenoma and cylindroma, these tumors have previously been considered to be negative for myoepithelial differentiation. All spiradenomas and cylindromas we studied demonstrated actin and/or S-100 protein positivity in basal epithelial cells, consistent with myoepithelial differentiation. The organization of actin and S-100 protein positivity displayed by the spiradenomas and cylindromas we studied suggests that the tumors are differentiated towards the secretory portion of the eccrine sweat gland.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalJournal of Cutaneous Pathology
Volume20
Issue number4
StatePublished - 1993

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Sweat Gland Adenoma
Adenoid Cystic Carcinoma
Acrospiroma
S100 Proteins
Pleomorphic Adenoma
Sweat Glands
Actins
Neoplasms
Mucin-1
Keratins
Eccrine Glands
Desmin
Antibodies
Actin Cytoskeleton
Smooth Muscle
Electron Microscopy
Epithelial Cells

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine

Cite this

Sweat gland adenomas : Immunohistochemical study with emphasis on myoepithelial differentiation. / Wiley, E. L.; Milchgrub, S.; Freeman, R. G.; Kim, E. S.

In: Journal of Cutaneous Pathology, Vol. 20, No. 4, 1993, p. 337-343.

Research output: Contribution to journalArticle

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