Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

Qingchun Tong, Chian Ping Ye, Juli E. Jones, Joel K. Elmquist, Bradford B. Lowell

Research output: Contribution to journalArticlepeer-review

373 Scopus citations

Abstract

The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron-specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.

Original languageEnglish (US)
Pages (from-to)998-1000
Number of pages3
JournalNature neuroscience
Volume11
Issue number9
DOIs
StatePublished - Sep 1 2008

ASJC Scopus subject areas

  • Neuroscience(all)

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