Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

Qingchun Tong, Chian Ping Ye, Juli E. Jones, Joel K. Elmquist, Bradford B. Lowell

Research output: Contribution to journalArticle

321 Citations (Scopus)

Abstract

The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron-specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.

Original languageEnglish (US)
Pages (from-to)998-1000
Number of pages3
JournalNature Neuroscience
Volume11
Issue number9
DOIs
StatePublished - Sep 2008

Fingerprint

Agouti-Related Protein
gamma-Aminobutyric Acid
Neurons
Ghrelin
Neuropeptide Y
Synaptic Transmission
Obesity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. / Tong, Qingchun; Ye, Chian Ping; Jones, Juli E.; Elmquist, Joel K.; Lowell, Bradford B.

In: Nature Neuroscience, Vol. 11, No. 9, 09.2008, p. 998-1000.

Research output: Contribution to journalArticle

Tong, Qingchun ; Ye, Chian Ping ; Jones, Juli E. ; Elmquist, Joel K. ; Lowell, Bradford B. / Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. In: Nature Neuroscience. 2008 ; Vol. 11, No. 9. pp. 998-1000.
@article{956f0bf87083481e8edc8f3bd9be4d55,
title = "Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance",
abstract = "The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron-specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.",
author = "Qingchun Tong and Ye, {Chian Ping} and Jones, {Juli E.} and Elmquist, {Joel K.} and Lowell, {Bradford B.}",
year = "2008",
month = "9",
doi = "10.1038/nn.2167",
language = "English (US)",
volume = "11",
pages = "998--1000",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

AU - Tong, Qingchun

AU - Ye, Chian Ping

AU - Jones, Juli E.

AU - Elmquist, Joel K.

AU - Lowell, Bradford B.

PY - 2008/9

Y1 - 2008/9

N2 - The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron-specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.

AB - The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron-specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.

UR - http://www.scopus.com/inward/record.url?scp=50249120768&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=50249120768&partnerID=8YFLogxK

U2 - 10.1038/nn.2167

DO - 10.1038/nn.2167

M3 - Article

VL - 11

SP - 998

EP - 1000

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 9

ER -