@article{956f0bf87083481e8edc8f3bd9be4d55,
title = "Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance",
abstract = "The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron-specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.",
author = "Qingchun Tong and Ye, {Chian Ping} and Jones, {Juli E.} and Elmquist, {Joel K.} and Lowell, {Bradford B.}",
note = "Funding Information: This work was supported by US National Institutes of Health grants (RO1 DK071051 and PO1 DK56116 to B.B.L.; RO1 DK071320, RO1 DK53301 and PO1 DK56116 to J.K.E.) and the Beth Israel Deaconess Medical Center Transgenic Facility, which is supported by the Boston Obesity Nutrition Research Center (P30 DK046200) and the Boston Area Diabetes Endocrinology Research Center (P30 DK057521). Q.T. is the recipient of a Pilot and Feasibility Award from the US National Institutes of Health–funded Boston Obesity Nutrition Research Center (P30 DK046200) and a Young Investigator Award from the North American Association for the Study of Obesity.",
year = "2008",
month = sep,
doi = "10.1038/nn.2167",
language = "English (US)",
volume = "11",
pages = "998--1000",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "9",
}