The synthesis by solid-phase methodology of two glycosylated analogs of somatostatin [Glc-Asn5]-SS and [NAcGlc-Asn5]-SS is described. These two analogs have been biologically tested on the secretion of pituitary growth hormone, pancreatic glucagon and insulin. The results show that glycosylation of somatostatin on the Asn5 residue decreases by a hundred fold the inhibition activity on GH release when tested invitro. Invivo, since the activity is similar to somatostatin the carbohydrates are probably removed by some enzymatic reaction and thus liberate the full activity of somatostatin.
|Original language||English (US)|
|Number of pages||9|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Nov 28 1979|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology