@article{bd9a81a1e4ce4fcb9ac033562355d302,
title = "Synthesis and biological evaluation of fully synthetic bryostatin analogues",
abstract = "The first members of a new class of designed bryostatin analogues are synthesized using a novel, convergent macrotransacetalization strategy. These simplified analogues, lacking the A-ring of bryostatin 1 and possessing a simplified B-ring, exhibit significant protein kinase C binding affinities and growth inhibitory activities against several human cancer cell lines.",
author = "Wender, {Paul A.} and {De Brabander}, Jef and Harran, {Patrick G.} and Hinkle, {Kevin W.} and Blaise Lippa and Pettit, {George R.}",
note = "Funding Information: Acknowledgments. Support of this work through a grant provided by the National Institutes of Health (CA31845) is gratefully acknowledged. HRMS analyses were performed at the UC San Francisco and the UC Riverside Mass Spectrometry Facilities. Fellowship support from the following sources is also gratefully recognized: Fulbright-Hays/NATO (J.D.B.), NIH (P.G.H., K.W,H.), and Eli Lilly (B.L.).",
year = "1998",
month = nov,
day = "19",
doi = "10.1016/S0040-4039(98)01955-8",
language = "English (US)",
volume = "39",
pages = "8625--8628",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "47",
}