Synthesis and biological evaluation of fully synthetic bryostatin analogues

Paul A. Wender, Jef De Brabander, Patrick G. Harran, Kevin W. Hinkle, Blaise Lippa, George R. Pettit

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48 Scopus citations

Abstract

The first members of a new class of designed bryostatin analogues are synthesized using a novel, convergent macrotransacetalization strategy. These simplified analogues, lacking the A-ring of bryostatin 1 and possessing a simplified B-ring, exhibit significant protein kinase C binding affinities and growth inhibitory activities against several human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)8625-8628
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number47
DOIs
Publication statusPublished - Nov 19 1998

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ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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