Synthesis and characterization of some organopolyphosphazenes and their controlled-release characteristics

K. B. Gudasi; R. S. Vadavi; B. Sreedhar; M. Sairam; N. B. Shelke; N. N. Mallikarjuna; P. V. Kulkarni; T. M. Aminahbavi

doi:10.1163/156855507780949227

Synthesis and characterization of some organopolyphosphazenes and their controlled-release characteristics

K. B. Gudasi, R. S. Vadavi, B. Sreedhar, M. Sairam, N. B. Shelke, N. N. Mallikarjuna, P. V. Kulkarni, T. M. Aminahbavi

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5 Scopus citations

Abstract

Two new organopolyphosphazenes, viz., poly[bis(3-methoxy benzyloxy) phosphazene] (POP-1) and poly[bis(4-fluoro-4′-oxybenzophenone)]phosphazene (POP-2), have been prepared by replacing chlorine atoms of dichloropolyphosphazene with 3-methoxy benzylalcohol and 4-fluoro4′- hydroxy-benzophenone. The polymers have been characterized by Fourier tranform infrared spectroscopy (FT-IR), ¹H- and ³¹P-nuclear magnetic resonance (NMR) spectra and thermogravimetric (TGA) analyses. The polymers have been developed as microspheres to study their controlled-release characteristics for indomethacin, an anti-inflammatory drug. Drug-loaded microspheres have been tested for in vitro release in pH 7.4 buffer media. FT-IR, ¹H- and ³¹P-NMR data confirmed the formation of polyorganophosphazenes substituted with 3-methoxy benzylalcohol and 4-fluoro-4′-hydroxy-benzophenone. In vitro drug-release studies have indicated sustained and controlled release of indomethacin through POP microspheres.

Original language	English (US)
Pages (from-to)	235-251
Number of pages	17
Journal	Designed Monomers and Polymers
Volume	10
Issue number	3
DOIs	https://doi.org/10.1163/156855507780949227
State	Published - 2007

Keywords

Controlled release
Microspheres
Organopolyphosphazenes
Spectral studies
Synthesis

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering
Polymers and Plastics
Materials Chemistry

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10.1163/156855507780949227

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@article{4d161f4eac694866a672b9aaac56eb80,

title = "Synthesis and characterization of some organopolyphosphazenes and their controlled-release characteristics",

abstract = "Two new organopolyphosphazenes, viz., poly[bis(3-methoxy benzyloxy) phosphazene] (POP-1) and poly[bis(4-fluoro-4′-oxybenzophenone)]phosphazene (POP-2), have been prepared by replacing chlorine atoms of dichloropolyphosphazene with 3-methoxy benzylalcohol and 4-fluoro4′- hydroxy-benzophenone. The polymers have been characterized by Fourier tranform infrared spectroscopy (FT-IR), 1H- and 31P-nuclear magnetic resonance (NMR) spectra and thermogravimetric (TGA) analyses. The polymers have been developed as microspheres to study their controlled-release characteristics for indomethacin, an anti-inflammatory drug. Drug-loaded microspheres have been tested for in vitro release in pH 7.4 buffer media. FT-IR, 1H- and 31P-NMR data confirmed the formation of polyorganophosphazenes substituted with 3-methoxy benzylalcohol and 4-fluoro-4′-hydroxy-benzophenone. In vitro drug-release studies have indicated sustained and controlled release of indomethacin through POP microspheres.",

keywords = "Controlled release, Microspheres, Organopolyphosphazenes, Spectral studies, Synthesis",

author = "Gudasi, {K. B.} and Vadavi, {R. S.} and B. Sreedhar and M. Sairam and Shelke, {N. B.} and Mallikarjuna, {N. N.} and Kulkarni, {P. V.} and Aminahbavi, {T. M.}",

note = "Funding Information: K. B. G. and R. S. V. thank the Department of Science and Technology, New Delhi, India, for a financial support (Grant SP/S1/PC-25/2002). T. M. A. thanks the University Grants Commission (UGC), New Delhi, India for a major financial support (Grant F1-41/2001/CPP-II) to establish the Center of Excellence in Polymer Science (CEPS). This paper is CEPS communication No. 126.",

year = "2007",

doi = "10.1163/156855507780949227",

language = "English (US)",

volume = "10",

pages = "235--251",

journal = "Designed Monomers and Polymers",

issn = "1385-772X",

publisher = "Taylor and Francis Ltd.",

number = "3",

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TY - JOUR

T1 - Synthesis and characterization of some organopolyphosphazenes and their controlled-release characteristics

AU - Gudasi, K. B.

AU - Vadavi, R. S.

AU - Sreedhar, B.

AU - Sairam, M.

AU - Shelke, N. B.

AU - Mallikarjuna, N. N.

AU - Kulkarni, P. V.

AU - Aminahbavi, T. M.

N1 - Funding Information: K. B. G. and R. S. V. thank the Department of Science and Technology, New Delhi, India, for a financial support (Grant SP/S1/PC-25/2002). T. M. A. thanks the University Grants Commission (UGC), New Delhi, India for a major financial support (Grant F1-41/2001/CPP-II) to establish the Center of Excellence in Polymer Science (CEPS). This paper is CEPS communication No. 126.

PY - 2007

Y1 - 2007

N2 - Two new organopolyphosphazenes, viz., poly[bis(3-methoxy benzyloxy) phosphazene] (POP-1) and poly[bis(4-fluoro-4′-oxybenzophenone)]phosphazene (POP-2), have been prepared by replacing chlorine atoms of dichloropolyphosphazene with 3-methoxy benzylalcohol and 4-fluoro4′- hydroxy-benzophenone. The polymers have been characterized by Fourier tranform infrared spectroscopy (FT-IR), 1H- and 31P-nuclear magnetic resonance (NMR) spectra and thermogravimetric (TGA) analyses. The polymers have been developed as microspheres to study their controlled-release characteristics for indomethacin, an anti-inflammatory drug. Drug-loaded microspheres have been tested for in vitro release in pH 7.4 buffer media. FT-IR, 1H- and 31P-NMR data confirmed the formation of polyorganophosphazenes substituted with 3-methoxy benzylalcohol and 4-fluoro-4′-hydroxy-benzophenone. In vitro drug-release studies have indicated sustained and controlled release of indomethacin through POP microspheres.

AB - Two new organopolyphosphazenes, viz., poly[bis(3-methoxy benzyloxy) phosphazene] (POP-1) and poly[bis(4-fluoro-4′-oxybenzophenone)]phosphazene (POP-2), have been prepared by replacing chlorine atoms of dichloropolyphosphazene with 3-methoxy benzylalcohol and 4-fluoro4′- hydroxy-benzophenone. The polymers have been characterized by Fourier tranform infrared spectroscopy (FT-IR), 1H- and 31P-nuclear magnetic resonance (NMR) spectra and thermogravimetric (TGA) analyses. The polymers have been developed as microspheres to study their controlled-release characteristics for indomethacin, an anti-inflammatory drug. Drug-loaded microspheres have been tested for in vitro release in pH 7.4 buffer media. FT-IR, 1H- and 31P-NMR data confirmed the formation of polyorganophosphazenes substituted with 3-methoxy benzylalcohol and 4-fluoro-4′-hydroxy-benzophenone. In vitro drug-release studies have indicated sustained and controlled release of indomethacin through POP microspheres.

KW - Controlled release

KW - Microspheres

KW - Organopolyphosphazenes

KW - Spectral studies

KW - Synthesis

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M3 - Article

AN - SCOPUS:34547361427

SN - 1385-772X

VL - 10

SP - 235

EP - 251

JO - Designed Monomers and Polymers

JF - Designed Monomers and Polymers

IS - 3

ER -

Synthesis and characterization of some organopolyphosphazenes and their controlled-release characteristics

Abstract

Keywords

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