Synthesis and characterization of some organopolyphosphazenes and their controlled-release characteristics

K. B. Gudasi, R. S. Vadavi, B. Sreedhar, M. Sairam, N. B. Shelke, N. N. Mallikarjuna, P. V. Kulkarni, T. M. Aminahbavi

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Two new organopolyphosphazenes, viz., poly[bis(3-methoxy benzyloxy) phosphazene] (POP-1) and poly[bis(4-fluoro-4′-oxybenzophenone)]phosphazene (POP-2), have been prepared by replacing chlorine atoms of dichloropolyphosphazene with 3-methoxy benzylalcohol and 4-fluoro4′- hydroxy-benzophenone. The polymers have been characterized by Fourier tranform infrared spectroscopy (FT-IR), 1H- and 31P-nuclear magnetic resonance (NMR) spectra and thermogravimetric (TGA) analyses. The polymers have been developed as microspheres to study their controlled-release characteristics for indomethacin, an anti-inflammatory drug. Drug-loaded microspheres have been tested for in vitro release in pH 7.4 buffer media. FT-IR, 1H- and 31P-NMR data confirmed the formation of polyorganophosphazenes substituted with 3-methoxy benzylalcohol and 4-fluoro-4′-hydroxy-benzophenone. In vitro drug-release studies have indicated sustained and controlled release of indomethacin through POP microspheres.

Original languageEnglish (US)
Pages (from-to)235-251
Number of pages17
JournalDesigned Monomers and Polymers
Volume10
Issue number3
DOIs
StatePublished - Aug 2 2007

    Fingerprint

Keywords

  • Controlled release
  • Microspheres
  • Organopolyphosphazenes
  • Spectral studies
  • Synthesis

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Gudasi, K. B., Vadavi, R. S., Sreedhar, B., Sairam, M., Shelke, N. B., Mallikarjuna, N. N., Kulkarni, P. V., & Aminahbavi, T. M. (2007). Synthesis and characterization of some organopolyphosphazenes and their controlled-release characteristics. Designed Monomers and Polymers, 10(3), 235-251. https://doi.org/10.1163/156855507780949227