Synthesis and MALDI-ToF characterization of dendronized poly(ethylene glycol)s

Brittany K. Myers, Joanna E. Lapucha, Scott M. Grayson

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Well-defined hybrids of linear poly(ethylene glycol)s (PEGs) and dendritic polyesters were prepared via the dendronization of the alcohol end groups of the mono and difunctional linear PEGs. Though useful for rudimentary product characterization, GPC and NMR could not verify the overall structural purity of these linear-dendritic hybrids. On the other hand, the detailed data provided by MALDI-ToF mass spectrometry enabled confirmation of the high structural purity of the dendronized PEGs at each step of the dendronization procedure. The well-defined number of functionalities on these dendronized PEGs, renders them particularly useful for research in the biomedical sphere where functionality and purity are of the utmost importance. The MALDI-ToF mass spectrometric approach described herein represents a valuable technique for detailed monitoring of these dendronization reactions, as well as a variety of other polymer end group modifications.

Original languageEnglish (US)
Pages (from-to)45-55
Number of pages11
JournalBrazilian Journal of Pharmaceutical Sciences
Volume49
Issue numberSPL.ISS.
DOIs
Publication statusPublished - Oct 4 2013

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Keywords

  • Dendrimers
  • Dendronized polymers
  • Dendrons
  • Poly(ethylene glycol)

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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