Synthesis and Structure Confirmation Of Compound D, A Proinflammatory Arachidonate Metabolite

Dong Soo Shin, Pendri Yadagiri, J R Falck, Jaime L. Masferrer, Michal L. Schwartzman

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

12(S)- and 12(R-Hydroxyeicosa-5(Z)-trienoic acids (7 and 8, respectively) and their 8(E)-analogues were prepared from L-glutamic acid. Only 8 was comparable by bioassay to natural compound D isolated from corneal epithelium.

Original languageEnglish (US)
Pages (from-to)3923-3926
Number of pages4
JournalTetrahedron Letters
Volume30
Issue number30
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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