Synthesis of 1233a analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme a synthase

T. Sunazuka, K. Tsuzuki, H. Kumagai, H. Tomoda, H. Tanaka, H. Nagashima, H. Hashizume, S. Omura

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Simple and efficient syntheses of 1233A analogs were developed and the inhibitory activity of the analogs against hydroxymethylglutaryl coenzyme A (HMG-CoA) synthase was determined. Study of the structure-activity relationships revealed that not only the geometry in β-lactone moiety but also the length of the carbon side chain is important for inhibitory activity against HMG-CoA synthase.

Original languageEnglish (US)
Pages (from-to)1139-1147
Number of pages9
JournalThe Journal of Antibiotics
Volume45
Issue number7
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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