Abstract
Simple and efficient syntheses of 1233A analogs were developed and the inhibitory activity of the analogs against hydroxymethylglutaryl coenzyme A (HMG-CoA) synthase was determined. Study of the structure-activity relationships revealed that not only the geometry in β-lactone moiety but also the length of the carbon side chain is important for inhibitory activity against HMG-CoA synthase.
Original language | English (US) |
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Pages (from-to) | 1139-1147 |
Number of pages | 9 |
Journal | The Journal of Antibiotics |
Volume | 45 |
Issue number | 7 |
DOIs | |
State | Published - 1992 |
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery