Systems approaches to unravel T cell function and therapeutic potential in autoimmune disease

Victor H. Salinas, Olaf Stuve

Research output: Contribution to journalReview articlepeer-review

Abstract

Producing Ag-specific immune responses constrained to target tissues or cells that can be engaged or disengaged at will is predicated on understanding the network of genes governing immune cell function, defining the rules underlying Ag specificity, and synthesizing the tools to engineer them. The successes and limitations of chimeric Ag receptor (CAR) T cells emphasize this goal, and advances in high-throughput sequencing, large-scale genomic screens, single-cell profiling, and genetic modification are providing the necessary data to bring it to fruition—including a broader application into the treatment of autoimmune diseases. In this review, we delve into the implementation of these developments, survey the relevant works, and propose a framework for generating the next generation of synthetic T cells informed by the principles learned from these systems approaches.

Original languageEnglish (US)
Pages (from-to)669-675
Number of pages7
JournalJournal of Immunology
Volume206
Issue number4
DOIs
StatePublished - Feb 15 2021

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'Systems approaches to unravel T cell function and therapeutic potential in autoimmune disease'. Together they form a unique fingerprint.

Cite this