Abstract
Allergic contact dermatitis is the quintessential example of a delayed-in-time and T-cellYmediated immune response. In the last decade, many of the molecular events required to initiate (or block) such a response have been uncovered. Textbook and journal reviews have emphasized the costimulatory requirements, with less focus on the coinhibitory signals that are of equal importance in understanding this central event of adaptive immunity. To fill this gap, we offer a compendium of discoveries characterizing the ligand-receptor pairs inhibiting T-cell activation and of selected illnesses and therapeutic applications that illuminate their role in health and disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 195-202 |
| Number of pages | 8 |
| Journal | Dermatitis |
| Volume | 23 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 2012 |
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ASJC Scopus subject areas
- Dermatology
- Immunology and Allergy
Cite this
T-cell inhibitors : A bench-to-bedside review. / Das, Shinjita; Ariizumi, Kiyoshi; Cruz, Ponciano D.
In: Dermatitis, Vol. 23, No. 5, 09.2012, p. 195-202.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - T-cell inhibitors
T2 - A bench-to-bedside review
AU - Das, Shinjita
AU - Ariizumi, Kiyoshi
AU - Cruz, Ponciano D
PY - 2012/9
Y1 - 2012/9
N2 - Allergic contact dermatitis is the quintessential example of a delayed-in-time and T-cellYmediated immune response. In the last decade, many of the molecular events required to initiate (or block) such a response have been uncovered. Textbook and journal reviews have emphasized the costimulatory requirements, with less focus on the coinhibitory signals that are of equal importance in understanding this central event of adaptive immunity. To fill this gap, we offer a compendium of discoveries characterizing the ligand-receptor pairs inhibiting T-cell activation and of selected illnesses and therapeutic applications that illuminate their role in health and disease.
AB - Allergic contact dermatitis is the quintessential example of a delayed-in-time and T-cellYmediated immune response. In the last decade, many of the molecular events required to initiate (or block) such a response have been uncovered. Textbook and journal reviews have emphasized the costimulatory requirements, with less focus on the coinhibitory signals that are of equal importance in understanding this central event of adaptive immunity. To fill this gap, we offer a compendium of discoveries characterizing the ligand-receptor pairs inhibiting T-cell activation and of selected illnesses and therapeutic applications that illuminate their role in health and disease.
UR - http://www.scopus.com/inward/record.url?scp=84871258545&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871258545&partnerID=8YFLogxK
U2 - 10.1097/DER.0b013e31826e43ed
DO - 10.1097/DER.0b013e31826e43ed
M3 - Article
C2 - 23010825
AN - SCOPUS:84871258545
VL - 23
SP - 195
EP - 202
JO - Dermatitis
JF - Dermatitis
SN - 1710-3568
IS - 5
ER -