Tailoring and recycling of deep eutectic solvents as sustainable and efficient extraction media

Kyung Min Jeong, Min Sang Lee, Min Woo Nam, Jing Zhao, Yan Jin, Dong Kyu Lee, Sung Won Kwon, Ji Hoon Jeong, Jeongmi Lee

Research output: Contribution to journalArticlepeer-review

131 Scopus citations


The present study demonstrates that deep eutectic solvents (DESs) with the highest extractability can be designed by combining effective DES components from screening diverse DESs. The extraction of polar ginseng saponins from white ginseng was used as a way to demonstrate the tuneability as well as recyclability of DESs. A newly designed ternary DES (GPS-5) composed of glycerol, l-proline, and sucrose at 9:4:1 was used as a sustainable and efficient extraction medium. Based on the anti-tumor activity on HCT-116 cancer cells, it was confirmed that GPS-5 was merely an extraction solvent with no influence of the bioactivity of the ginsenosides extracted. Excellent recovery of the extracted saponins was easily achieved through solid-phase extraction (SPE). Recycling of the DES was accomplished by simple freeze-drying of the washed solutions from the SPE. The extraction efficiencies of the DESs recycled once, twice, and thrice were 92%, 85%, and 83% of that of the freshly synthesized solvent.

Original languageEnglish (US)
Pages (from-to)10-17
Number of pages8
JournalJournal of Chromatography A
StatePublished - Dec 11 2015


  • Deep eutectic solvent
  • Ginsenoside
  • Green extraction
  • Solvent design
  • Solvent recycling

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry


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