Tailoring and recycling of deep eutectic solvents as sustainable and efficient extraction media

Kyung Min Jeong, Min Sang Lee, Min Woo Nam, Jing Zhao, Yan Jin, Dong Kyu Lee, Sung Won Kwon, Ji Hoon Jeong, Jeongmi Lee

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The present study demonstrates that deep eutectic solvents (DESs) with the highest extractability can be designed by combining effective DES components from screening diverse DESs. The extraction of polar ginseng saponins from white ginseng was used as a way to demonstrate the tuneability as well as recyclability of DESs. A newly designed ternary DES (GPS-5) composed of glycerol, l-proline, and sucrose at 9:4:1 was used as a sustainable and efficient extraction medium. Based on the anti-tumor activity on HCT-116 cancer cells, it was confirmed that GPS-5 was merely an extraction solvent with no influence of the bioactivity of the ginsenosides extracted. Excellent recovery of the extracted saponins was easily achieved through solid-phase extraction (SPE). Recycling of the DES was accomplished by simple freeze-drying of the washed solutions from the SPE. The extraction efficiencies of the DESs recycled once, twice, and thrice were 92%, 85%, and 83% of that of the freshly synthesized solvent.

Original languageEnglish (US)
Pages (from-to)10-17
Number of pages8
JournalJournal of Chromatography A
Volume1424
DOIs
StatePublished - Dec 11 2015

Fingerprint

Recycling
Eutectics
Saponins
Panax
Solid Phase Extraction
Global positioning system
Ginsenosides
HCT116 Cells
Solvent extraction
Freeze Drying
Bioactivity
Proline
Glycerol
Sucrose
Tumors
Drying
Screening
Neoplasms
Cells
Recovery

Keywords

  • Deep eutectic solvent
  • Ginsenoside
  • Green extraction
  • Solvent design
  • Solvent recycling

ASJC Scopus subject areas

  • Analytical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

Tailoring and recycling of deep eutectic solvents as sustainable and efficient extraction media. / Jeong, Kyung Min; Lee, Min Sang; Nam, Min Woo; Zhao, Jing; Jin, Yan; Lee, Dong Kyu; Kwon, Sung Won; Jeong, Ji Hoon; Lee, Jeongmi.

In: Journal of Chromatography A, Vol. 1424, 11.12.2015, p. 10-17.

Research output: Contribution to journalArticle

Jeong, KM, Lee, MS, Nam, MW, Zhao, J, Jin, Y, Lee, DK, Kwon, SW, Jeong, JH & Lee, J 2015, 'Tailoring and recycling of deep eutectic solvents as sustainable and efficient extraction media', Journal of Chromatography A, vol. 1424, pp. 10-17. https://doi.org/10.1016/j.chroma.2015.10.083
Jeong, Kyung Min ; Lee, Min Sang ; Nam, Min Woo ; Zhao, Jing ; Jin, Yan ; Lee, Dong Kyu ; Kwon, Sung Won ; Jeong, Ji Hoon ; Lee, Jeongmi. / Tailoring and recycling of deep eutectic solvents as sustainable and efficient extraction media. In: Journal of Chromatography A. 2015 ; Vol. 1424. pp. 10-17.
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