Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma

Xiang Chen, Elizabeth Stewart, AnangA Shelat, Chunxu Qu, Armita Bahrami, Mark Hatley, Gang Wu, Cori Bradley, Justina McEvoy, Alberto Pappo, Sheri Spunt, MarcusB Valentine, Virginia Valentine, Fred Krafcik, WalterH Lang, Monika Wierdl, Lyudmila Tsurkan, Viktor Tolleman, SaraM Federico, Chris MortonCharles Lu, Li Ding, John Easton, Michael Rusch, Panduka Nagahawatte, Jianmin Wang, Matthew Parker, Lei Wei, Erin Hedlund, David Finkelstein, Michael Edmonson, Sheila Shurtleff, Kristy Boggs, Heather Mulder, Donald Yergeau, Steve Skapek, DouglasS Hawkins, Nilsa Ramirez, PhilipM Potter, JohnA Sandoval, AndrewM Davidoff, ElaineR Mardis, RichardK Wilson, Jinghui Zhang, JamesR Downing, MichaelA Dyer

Research output: Contribution to journalArticlepeer-review

207 Scopus citations


Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes, embryonal and alveolar, each with distinct clinical, molecular, and genetic features. Genomic analysis shows that embryonal tumors have more structural and copy number variations than alveolar tumors. Mutations in the RAS/NF1 pathway are significantly associated with intermediate- and high-risk embryonal rhabdomyosarcomas (ERMS). In contrast, alveolar rhabdomyosarcomas (ARMS) have fewer genetic lesions overall and no known recurrently mutated cancer consensus genes. To identify therapeutics for ERMS, we developed and characterized orthotopic xenografts of tumors that were sequenced in our study. High-throughput screening of primary cultures derived from those xenografts identified oxidative stress as a pathway of therapeutic relevance for ERMS.

Original languageEnglish (US)
Pages (from-to)710-724
Number of pages15
JournalCancer Cell
Issue number6
StatePublished - Dec 9 2013

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research


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