Targeting telomerase for cancer therapeutics

J. W. Shay, W. N. Keith

Research output: Contribution to journalShort survey

133 Scopus citations

Abstract

One of the hallmarks of advanced malignancies is continuous cell growth and this almost universally correlates with the reactivation of telomerase. Although there is still much we do not understand about the regulation of telomerase, it remains a very attractive and novel target for cancer therapeutics. Several clinical trials have been initiated, and in this review we highlight some of the most promising approaches and conclude by speculating on the role of telomerase in cancer stem cells.

Original languageEnglish (US)
Pages (from-to)677-683
Number of pages7
JournalBritish journal of cancer
Volume98
Issue number4
DOIs
StatePublished - Feb 26 2008

Keywords

  • Ageing
  • Targeted therapeutics
  • Telomeres

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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