Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy

Haidong Tang, Xiangyan Qiu, Casey Timmerman, Yang Xin Fu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tumor microenvironments (TME) are usually immunosuppressive and prevent lymphocyte priming. Recent clinical trials have shown that cancer immunotherapy such as immune checkpoint inhibitors can induce unprecedented durable responses in patients with a variety of cancers. Tertiary lymphoid structures (TLS) can form inside or adjacent to tumor tissues due to persistent inflammation. The formation of TLS facilitates lymphocyte trafficking and infiltration into tumor tissues. It can also support effective antigen presentation and lymphocyte activation. Thus, TLS have become an intriguing target to manipulate antitumor immunity. Several therapeutics targeting TLS have been developed and shown promising antitumor effects in various mouse models. In this chapter, we describe the general approach to establish transplantable mouse tumor models for the study of immunotherapy. We introduce the strategies for therapy through systemic or local treatment targeting TLS. We also present approaches to evaluate the antitumor immune responses provoked by the therapies.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages275-286
Number of pages12
DOIs
StatePublished - Jan 1 2018

Publication series

NameMethods in Molecular Biology
Volume1845
ISSN (Print)1064-3745

Fingerprint

Immunotherapy
Neoplasms
Lymphocytes
Tumor Microenvironment
Antigen Presentation
Therapeutics
Immunosuppressive Agents
Lymphocyte Activation
Immunity
Tertiary Lymphoid Structures
Clinical Trials
Inflammation

Keywords

  • Cancer
  • Immunotherapy
  • Mouse tumor model
  • Tertiary lymphoid structure

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Tang, H., Qiu, X., Timmerman, C., & Fu, Y. X. (2018). Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy. In Methods in Molecular Biology (pp. 275-286). (Methods in Molecular Biology; Vol. 1845). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-8709-2_16

Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy. / Tang, Haidong; Qiu, Xiangyan; Timmerman, Casey; Fu, Yang Xin.

Methods in Molecular Biology. Humana Press Inc., 2018. p. 275-286 (Methods in Molecular Biology; Vol. 1845).

Research output: Chapter in Book/Report/Conference proceedingChapter

Tang, H, Qiu, X, Timmerman, C & Fu, YX 2018, Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1845, Humana Press Inc., pp. 275-286. https://doi.org/10.1007/978-1-4939-8709-2_16
Tang H, Qiu X, Timmerman C, Fu YX. Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy. In Methods in Molecular Biology. Humana Press Inc. 2018. p. 275-286. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-8709-2_16
Tang, Haidong ; Qiu, Xiangyan ; Timmerman, Casey ; Fu, Yang Xin. / Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy. Methods in Molecular Biology. Humana Press Inc., 2018. pp. 275-286 (Methods in Molecular Biology).
@inbook{210e1ae7f34e47e9a042ffda017e6271,
title = "Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy",
abstract = "Tumor microenvironments (TME) are usually immunosuppressive and prevent lymphocyte priming. Recent clinical trials have shown that cancer immunotherapy such as immune checkpoint inhibitors can induce unprecedented durable responses in patients with a variety of cancers. Tertiary lymphoid structures (TLS) can form inside or adjacent to tumor tissues due to persistent inflammation. The formation of TLS facilitates lymphocyte trafficking and infiltration into tumor tissues. It can also support effective antigen presentation and lymphocyte activation. Thus, TLS have become an intriguing target to manipulate antitumor immunity. Several therapeutics targeting TLS have been developed and shown promising antitumor effects in various mouse models. In this chapter, we describe the general approach to establish transplantable mouse tumor models for the study of immunotherapy. We introduce the strategies for therapy through systemic or local treatment targeting TLS. We also present approaches to evaluate the antitumor immune responses provoked by the therapies.",
keywords = "Cancer, Immunotherapy, Mouse tumor model, Tertiary lymphoid structure",
author = "Haidong Tang and Xiangyan Qiu and Casey Timmerman and Fu, {Yang Xin}",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/978-1-4939-8709-2_16",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "275--286",
booktitle = "Methods in Molecular Biology",

}

TY - CHAP

T1 - Targeting Tertiary Lymphoid Structures for Tumor Immunotherapy

AU - Tang, Haidong

AU - Qiu, Xiangyan

AU - Timmerman, Casey

AU - Fu, Yang Xin

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Tumor microenvironments (TME) are usually immunosuppressive and prevent lymphocyte priming. Recent clinical trials have shown that cancer immunotherapy such as immune checkpoint inhibitors can induce unprecedented durable responses in patients with a variety of cancers. Tertiary lymphoid structures (TLS) can form inside or adjacent to tumor tissues due to persistent inflammation. The formation of TLS facilitates lymphocyte trafficking and infiltration into tumor tissues. It can also support effective antigen presentation and lymphocyte activation. Thus, TLS have become an intriguing target to manipulate antitumor immunity. Several therapeutics targeting TLS have been developed and shown promising antitumor effects in various mouse models. In this chapter, we describe the general approach to establish transplantable mouse tumor models for the study of immunotherapy. We introduce the strategies for therapy through systemic or local treatment targeting TLS. We also present approaches to evaluate the antitumor immune responses provoked by the therapies.

AB - Tumor microenvironments (TME) are usually immunosuppressive and prevent lymphocyte priming. Recent clinical trials have shown that cancer immunotherapy such as immune checkpoint inhibitors can induce unprecedented durable responses in patients with a variety of cancers. Tertiary lymphoid structures (TLS) can form inside or adjacent to tumor tissues due to persistent inflammation. The formation of TLS facilitates lymphocyte trafficking and infiltration into tumor tissues. It can also support effective antigen presentation and lymphocyte activation. Thus, TLS have become an intriguing target to manipulate antitumor immunity. Several therapeutics targeting TLS have been developed and shown promising antitumor effects in various mouse models. In this chapter, we describe the general approach to establish transplantable mouse tumor models for the study of immunotherapy. We introduce the strategies for therapy through systemic or local treatment targeting TLS. We also present approaches to evaluate the antitumor immune responses provoked by the therapies.

KW - Cancer

KW - Immunotherapy

KW - Mouse tumor model

KW - Tertiary lymphoid structure

UR - http://www.scopus.com/inward/record.url?scp=85052528786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052528786&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-8709-2_16

DO - 10.1007/978-1-4939-8709-2_16

M3 - Chapter

T3 - Methods in Molecular Biology

SP - 275

EP - 286

BT - Methods in Molecular Biology

PB - Humana Press Inc.

ER -