Abstract
Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor's concomitant androgen or estrogen receptor activity.
| Original language | English (US) |
|---|---|
| Article number | 7531 |
| Journal | Science Translational Medicine |
| Volume | 7 |
| Issue number | 305 |
| DOIs | |
| State | Published - Sep 16 2015 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Targeting the glucocorticoid receptor in breast and prostate cancers. / Kach, Jacob; Conzen, Suzanne D.; Szmulewitz, Russell Z.
In: Science Translational Medicine, Vol. 7, No. 305, 7531, 16.09.2015.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Targeting the glucocorticoid receptor in breast and prostate cancers
AU - Kach, Jacob
AU - Conzen, Suzanne D.
AU - Szmulewitz, Russell Z.
PY - 2015/9/16
Y1 - 2015/9/16
N2 - Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor's concomitant androgen or estrogen receptor activity.
AB - Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor's concomitant androgen or estrogen receptor activity.
UR - http://www.scopus.com/inward/record.url?scp=84941755779&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941755779&partnerID=8YFLogxK
U2 - 10.1126/scitranslmed.aac7531
DO - 10.1126/scitranslmed.aac7531
M3 - Review article
C2 - 26378243
AN - SCOPUS:84941755779
VL - 7
JO - Science Translational Medicine
JF - Science Translational Medicine
SN - 1946-6234
IS - 305
M1 - 7531
ER -