Targeting the glucocorticoid receptor in breast and prostate cancers

Jacob Kach, Suzanne D. Conzen, Russell Z. Szmulewitz

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor's concomitant androgen or estrogen receptor activity.

Original languageEnglish (US)
Article number7531
JournalScience Translational Medicine
Volume7
Issue number305
DOIs
StatePublished - Sep 16 2015
Externally publishedYes

Fingerprint

Glucocorticoid Receptors
Prostatic Neoplasms
Breast Neoplasms
Steroid Receptors
Androgen Receptors
Cytoplasmic and Nuclear Receptors
Estrogen Receptors
Androgens
Neoplasms
Estrogens

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Targeting the glucocorticoid receptor in breast and prostate cancers. / Kach, Jacob; Conzen, Suzanne D.; Szmulewitz, Russell Z.

In: Science Translational Medicine, Vol. 7, No. 305, 7531, 16.09.2015.

Research output: Contribution to journalReview article

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