Targeting the glucocorticoid receptor in breast and prostate cancers

Jacob Kach; Suzanne D. Conzen; Russell Z. Szmulewitz

doi:10.1126/scitranslmed.aac7531

Targeting the glucocorticoid receptor in breast and prostate cancers

Jacob Kach, Suzanne D. Conzen, Russell Z. Szmulewitz

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor's concomitant androgen or estrogen receptor activity.

Original language	English (US)
Article number	7531
Journal	Science translational medicine
Volume	7
Issue number	305
DOIs	https://doi.org/10.1126/scitranslmed.aac7531
State	Published - Sep 16 2015
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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abstract = "Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor's concomitant androgen or estrogen receptor activity.",

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