TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease

Eileen H. Bigio, Manjari Mishra, Kimmo J. Hatanpaa, Charles L. White, Nancy Johnson, Alfred Rademaker, Bing Bing Weitner, Han Xiang Deng, Steven D. Dubner, Sandra Weintraub, Marsel Mesulam

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The clinical syndrome of primary progressive aphasia (PPA) can be associated with a variety of neuropathologic diagnoses at autopsy. Thirty percent of cases have Alzheimer disease (AD) pathology, most often in the usual distribution, which defies principles of brain-behavior organization, in that aphasia is not symptomatic of limbic disease. The present study investigated whether concomitant TDP-43 pathology could resolve the lack of clinico-anatomic concordance. In this paper, 16 cases of clinical PPA and 10 cases of primarily non-aphasic frontotemporal dementia (FTD), all with AD pathology, were investigated to determine whether their atypical clinical phenotypes reflected the presence of additional TDP-43 pathology. A comparison group consisted of 27 cases of pathologic AD with the typical amnestic clinical phenotype of probable AD. Concomitant TDP-43 pathology was discovered in only three of the FTD and PPA but in more than half of the typical amnestic clinical phenotypes. Hippocampal sclerosis (HS) was closely associated with TDP-43 pathology when all groups were combined for analysis. Therefore, the clinical phenotypes of PPA and FTD in cases with pathologic AD are only rarely associated with TDP-43 proteinopathy. Furthermore, medial temporal TDP-43 pathology is more tightly linked to HS than to clinical phenotype. These findings challenge the current notions about clinicopathologic correlation, especially about the role of multiple pathologies.

Original languageEnglish (US)
Pages (from-to)43-54
Number of pages12
JournalActa Neuropathologica
Volume120
Issue number1
DOIs
StatePublished - Jul 2010

Fingerprint

Primary Progressive Aphasia
Frontotemporal Dementia
Alzheimer Disease
Pathology
Phenotype
Sclerosis
TDP-43 Proteinopathies
Aphasia
Autopsy
Organizations

Keywords

  • Alzheimer disease
  • Frontotemporal dementia
  • FTLD-TDP
  • Hippocampal sclerosis
  • Primary progressive aphasia
  • TDP-43 proteinopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Cellular and Molecular Neuroscience

Cite this

TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease. / Bigio, Eileen H.; Mishra, Manjari; Hatanpaa, Kimmo J.; White, Charles L.; Johnson, Nancy; Rademaker, Alfred; Weitner, Bing Bing; Deng, Han Xiang; Dubner, Steven D.; Weintraub, Sandra; Mesulam, Marsel.

In: Acta Neuropathologica, Vol. 120, No. 1, 07.2010, p. 43-54.

Research output: Contribution to journalArticle

Bigio, EH, Mishra, M, Hatanpaa, KJ, White, CL, Johnson, N, Rademaker, A, Weitner, BB, Deng, HX, Dubner, SD, Weintraub, S & Mesulam, M 2010, 'TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease', Acta Neuropathologica, vol. 120, no. 1, pp. 43-54. https://doi.org/10.1007/s00401-010-0681-2
Bigio, Eileen H. ; Mishra, Manjari ; Hatanpaa, Kimmo J. ; White, Charles L. ; Johnson, Nancy ; Rademaker, Alfred ; Weitner, Bing Bing ; Deng, Han Xiang ; Dubner, Steven D. ; Weintraub, Sandra ; Mesulam, Marsel. / TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease. In: Acta Neuropathologica. 2010 ; Vol. 120, No. 1. pp. 43-54.
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