Techniques in X-ray computed tomography in the evaluation of drug release systems and their application

Agata A. Exner, Jinming Gao, David L. Wilson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Advancement of site-specific drug delivery systems has been hampered by the shortage of direct techniques for sampling and analysis of drug concentrations at the site of action. Because the potential target is often deeply imbedded within an organ, the local concentration of a drug delivered via implantable devices and its movement in tissue and vasculature (regarded as one significant aspect of pharmacokinetics) are often difficult to obtain with traditional methods like plasma and urine analysis, and alternative methods are highly sought after. Imaging is a natural candidate for this application. Thanks to modern technology, clinical imaging modalities with high spatial and temporal resolution combined with exceptional sensitivity and ease of use have greatly impacted the current diagnosis and treatment of diseases. Although all types of modalities are excellent candidates for pharmacokinetic imaging, X-ray Computed Tomography (CT) possesses a unique combination of speed, resolution and inherent simplicity in quantitative analysis that makes it an attractive choice. This chapter provides a general overview of CT methods in pharmacokinetic imaging with a specific application to the development and evaluation of a drug release system for local chemotherapy of liver tumors.

Original languageEnglish (US)
Title of host publicationMedical Imaging Systems Technology: Volume 2: Modalities
PublisherWorld Scientific Publishing Co.
Pages105-132
Number of pages28
ISBN (Print)9789812701077, 9812563644, 9789812569929
DOIs
StatePublished - Jan 1 2005

Keywords

  • Pharmacokinetic imaging
  • Site-specific drug release system
  • X-ray computed tomography

ASJC Scopus subject areas

  • Medicine(all)

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    Exner, A. A., Gao, J., & Wilson, D. L. (2005). Techniques in X-ray computed tomography in the evaluation of drug release systems and their application. In Medical Imaging Systems Technology: Volume 2: Modalities (pp. 105-132). World Scientific Publishing Co.. https://doi.org/10.1142/9789812701077_0005