Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again

Nicholas R. Forsyth, Woodring E. Wright, Jerry W. Shay

Research output: Contribution to journalArticle

257 Citations (Scopus)

Abstract

Telomerase is a ribonucleoprotein complex that catalyses the addition of TTAGGG repeats onto telomeres, repetitive DNA structures found at the ends of linear chromosomes. The majority of human somatic tissues do not display telomerase activity and undergo telomeric shortening with consecutive divisions. This telomeric shortening results in replicative senescence in vitro and likely in vivo. Telomerase activity is present in the vast majority of tumors, preventing telomeric shortening and thereby enabling indefinite cell divisions. Telomerase activity is regulated throughout human development, undergoing silencing in almost all organ systems from embryogenesis onwards. However, regulated telomerase activity is seen in basal/stem cell compartments of highly regenerative tissues, such as those of the immune system, skin, and intestine. Avian species display telomerase repression and telomeric shortening similar to that seen in humans. However, rodents retain telomerase-competency throughout their lifespan and have not been shown to display division-dependent telomere shortening. The regulation of telomerase activity in plants is less well understood, although early indications suggest ubiquitous competency. The aim of this review is to present current data regarding developmental regulation of telomerase in humans, mice, chickens and flowering plants. Differentiation, quiescence and telomerase activity regulation will then be addressed in three human representative tissue systems; blood, skin, and intestine. We will also highlight similarities, differences and misconceptions in the developing field of telomere and telomerase biology.

Original languageEnglish (US)
Pages (from-to)188-197
Number of pages10
JournalDifferentiation
Volume69
Issue number4-5
DOIs
StatePublished - Jan 2002

Fingerprint

Telomerase
Telomere
Intestines
Telomere Shortening
Skin
Ribonucleoproteins
Cell Aging
Human Development
Cell Division
Embryonic Development
Chickens
Immune System
Rodentia
Stem Cells
Chromosomes

Keywords

  • Development
  • Differentiation
  • Telomerase
  • Telomere

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Developmental Biology
  • Cell Biology

Cite this

Telomerase and differentiation in multicellular organisms : Turn it off, turn it on, and turn it off again. / Forsyth, Nicholas R.; Wright, Woodring E.; Shay, Jerry W.

In: Differentiation, Vol. 69, No. 4-5, 01.2002, p. 188-197.

Research output: Contribution to journalArticle

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