Telomerase in cancer and aging

Meaghan P. Granger, Woodring E. Wright, Jerry W. Shay

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

The telomere-telomerase hypothesis is the science of cellular aging (senescence) and cancer. The ends of chromosomes, telomeres, count the number of divisions a cell can undergo before entering permanent growth arrest. As divisions are being counted, events occur on the cellular and molecular level, which may either delay or hasten this arrest. As humans age, a particular concern is the accumulation of events that lead to the progression of cancer. Telomerase is a mechanism that most normal cells do not possess, but almost all cancer cells acquire, to overcome their mortality and extend their lifespan. This review aims to provide a comprehensive understanding of the role of telomerase in cancer development, progression, diagnosis, and in the future, treatment. The ultimate goal of telomerase research is to use our understanding to develop anti-telomerase therapies, an almost universal tumor target.

Original languageEnglish (US)
Pages (from-to)29-40
Number of pages12
JournalCritical Reviews in Oncology/Hematology
Volume41
Issue number1
DOIs
StatePublished - 2002

Fingerprint

Telomerase
Cell Aging
Telomere
Neoplasms
Cell Division
Chromosomes
Mortality
Growth
Research

Keywords

  • Cancer
  • Immunosenescence
  • Replicative aging
  • Senescence
  • Telomerase
  • Telomerase inhibitors
  • Telomere

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Telomerase in cancer and aging. / Granger, Meaghan P.; Wright, Woodring E.; Shay, Jerry W.

In: Critical Reviews in Oncology/Hematology, Vol. 41, No. 1, 2002, p. 29-40.

Research output: Contribution to journalArticle

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