Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology

Woodring E. Wright, Jerry W. Shay

Research output: Contribution to journalArticle

307 Citations (Scopus)

Abstract

Cells from the telomerase knockout mouse immortalize with an approximately ten million-fold greater frequency than human cells. In this commentary, Wright and Shay discuss the implications of this difference between mice and men and its relationship to cancer.

Original languageEnglish (US)
Pages (from-to)849-851
Number of pages3
JournalNature Medicine
Volume6
Issue number8
DOIs
StatePublished - Aug 2000

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Telomerase
Telomere
Cells
Knockout Mice
Neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Telomere dynamics in cancer progression and prevention : Fundamental differences in human and mouse telomere biology. / Wright, Woodring E.; Shay, Jerry W.

In: Nature Medicine, Vol. 6, No. 8, 08.2000, p. 849-851.

Research output: Contribution to journalArticle

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