Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery

Shawn He; George Tourkakis; Oleg Berezin; Nikolay Gerasimchuk; Hairong Zhang; Haiying Zhou; Asaf Izraely; Walter J. Akers; Mikhail Y. Berezin

doi:10.1039/c6tc00122j

Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery

Shawn He, George Tourkakis, Oleg Berezin, Nikolay Gerasimchuk, Hairong Zhang, Haiying Zhou, Asaf Izraely, Walter J. Akers, Mikhail Y. Berezin

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infrared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40 °C to 65 °C.

Original language	English (US)
Pages (from-to)	3028-3035
Number of pages	8
Journal	Journal of Materials Chemistry C
Volume	4
Issue number	14
DOIs	https://doi.org/10.1039/c6tc00122j
State	Published - Apr 14 2016
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
Materials Chemistry

Access to Document

10.1039/c6tc00122j

Cite this

@article{5f0b4f82dd1747acba5e5e886fc64f50,

title = "Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery",

abstract = "Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infrared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40 °C to 65 °C.",

author = "Shawn He and George Tourkakis and Oleg Berezin and Nikolay Gerasimchuk and Hairong Zhang and Haiying Zhou and Asaf Izraely and Akers, {Walter J.} and Berezin, {Mikhail Y.}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

month = apr,

day = "14",

doi = "10.1039/c6tc00122j",

language = "English (US)",

volume = "4",

pages = "3028--3035",

journal = "Journal of Materials Chemistry C",

issn = "2050-7526",

publisher = "Royal Society of Chemistry",

number = "14",

}

TY - JOUR

T1 - Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery

AU - He, Shawn

AU - Tourkakis, George

AU - Berezin, Oleg

AU - Gerasimchuk, Nikolay

AU - Zhang, Hairong

AU - Zhou, Haiying

AU - Izraely, Asaf

AU - Akers, Walter J.

AU - Berezin, Mikhail Y.

PY - 2016/4/14

Y1 - 2016/4/14

N2 - Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infrared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40 °C to 65 °C.

AB - Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infrared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40 °C to 65 °C.

UR - http://www.scopus.com/inward/record.url?scp=84963831255&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963831255&partnerID=8YFLogxK

U2 - 10.1039/c6tc00122j

DO - 10.1039/c6tc00122j

M3 - Article

AN - SCOPUS:84963831255

SN - 2050-7526

VL - 4

SP - 3028

EP - 3035

JO - Journal of Materials Chemistry C

JF - Journal of Materials Chemistry C

IS - 14

ER -

Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this