Ten-year survival of patients with small-cell lung cancer treated with combination chemotherapy with or without irradiation

Bruce E. Johnson, Jane Grayson, Robert W. Makuch, R. Ilona Linnoila, Michael J. Anderson, Martin H. Cohen, Eli Glatstein, John D. Minna, Daniel C. Ihde

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91 Scopus citations

Abstract

We evaluated the 10- to 15-year outcome of 252 patients with small-cell lung cancer entered into therapeutic clinical trials with or without chest and cranial irradiation. Thirty-two patients (13%) survived free of cancer for 2 or more years. Twelve patients (5%) survived at least 10 years free of cancer, and 10 patients are currently alive and free of cancer beyond 10 years. Six of these 10 patients currently function at a level comparable with that before diagnosis. The other 22 patients who were cancer-free at 2 years have died. Nine patients died from recurrent small-cell lung cancer 2 to 6.2 years after initiation of chemotherapy. Five died from non-small-cell lung cancer, three died of other malignancies, and five died of causes other than cancer. A small fraction of patients with small-cell lung cancer are cured of their original malignancy, but these patients remain at high risk for second cancers and death from other causes.

Original languageEnglish (US)
Pages (from-to)396-401
Number of pages6
JournalJournal of Clinical Oncology
Volume8
Issue number3
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Johnson, B. E., Grayson, J., Makuch, R. W., Linnoila, R. I., Anderson, M. J., Cohen, M. H., Glatstein, E., Minna, J. D., & Ihde, D. C. (1990). Ten-year survival of patients with small-cell lung cancer treated with combination chemotherapy with or without irradiation. Journal of Clinical Oncology, 8(3), 396-401. https://doi.org/10.1200/JCO.1990.8.3.396