Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes

Zibo Li, Hancheng Cai, Matthew Hassink, Melissa L. Blackman, Richard C D Brown, Peter S. Conti, Joseph M. Fox

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an 18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

Original languageEnglish (US)
Pages (from-to)8043-8045
Number of pages3
JournalChemical Communications
Volume46
Issue number42
DOIs
StatePublished - Nov 14 2010

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Li, Z., Cai, H., Hassink, M., Blackman, M. L., Brown, R. C. D., Conti, P. S., & Fox, J. M. (2010). Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes. Chemical Communications, 46(42), 8043-8045. https://doi.org/10.1039/c0cc03078c

Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes. / Li, Zibo; Cai, Hancheng; Hassink, Matthew; Blackman, Melissa L.; Brown, Richard C D; Conti, Peter S.; Fox, Joseph M.

In: Chemical Communications, Vol. 46, No. 42, 14.11.2010, p. 8043-8045.

Research output: Contribution to journalArticle

Li, Z, Cai, H, Hassink, M, Blackman, ML, Brown, RCD, Conti, PS & Fox, JM 2010, 'Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes', Chemical Communications, vol. 46, no. 42, pp. 8043-8045. https://doi.org/10.1039/c0cc03078c
Li, Zibo ; Cai, Hancheng ; Hassink, Matthew ; Blackman, Melissa L. ; Brown, Richard C D ; Conti, Peter S. ; Fox, Joseph M. / Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes. In: Chemical Communications. 2010 ; Vol. 46, No. 42. pp. 8043-8045.
@article{9476610098e44cd4a9b3d176ec35bb89,
title = "Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes",
abstract = "A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an 18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.",
author = "Zibo Li and Hancheng Cai and Matthew Hassink and Blackman, {Melissa L.} and Brown, {Richard C D} and Conti, {Peter S.} and Fox, {Joseph M.}",
year = "2010",
month = "11",
day = "14",
doi = "10.1039/c0cc03078c",
language = "English (US)",
volume = "46",
pages = "8043--8045",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "42",

}

TY - JOUR

T1 - Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes

AU - Li, Zibo

AU - Cai, Hancheng

AU - Hassink, Matthew

AU - Blackman, Melissa L.

AU - Brown, Richard C D

AU - Conti, Peter S.

AU - Fox, Joseph M.

PY - 2010/11/14

Y1 - 2010/11/14

N2 - A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an 18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

AB - A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an 18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

UR - http://www.scopus.com/inward/record.url?scp=77958479732&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958479732&partnerID=8YFLogxK

U2 - 10.1039/c0cc03078c

DO - 10.1039/c0cc03078c

M3 - Article

VL - 46

SP - 8043

EP - 8045

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 42

ER -