Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes

Zibo Li, Hancheng Cai, Matthew Hassink, Melissa L. Blackman, Richard C D Brown, Peter S. Conti, Joseph M. Fox

Research output: Contribution to journalArticle

120 Scopus citations

Abstract

A radiolabeling method for bioconjugation based on the Diels-Alder reaction between 3,6-diaryl-s-tetrazines and an 18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

Original languageEnglish (US)
Pages (from-to)8043-8045
Number of pages3
JournalChemical Communications
Volume46
Issue number42
DOIs
StatePublished - Nov 14 2010

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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  • Cite this

    Li, Z., Cai, H., Hassink, M., Blackman, M. L., Brown, R. C. D., Conti, P. S., & Fox, J. M. (2010). Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes. Chemical Communications, 46(42), 8043-8045. https://doi.org/10.1039/c0cc03078c