TGF-β family signaling in mesenchymal differentiation

Ingo Grafe, Stefanie Alexander, Jonathan R. Peterson, Taylor Nicholas Snider, Benjamin Levi, Brendan Lee, Yuji Mishina

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Mesenchymal stem cells (MSCs) can differentiate into several lineages during development and also contribute to tissue homeostasis and regeneration, although the requirements for both may be distinct. MSC lineage commitment and progression in differentiation are regulated by members of the transforming growth factor-β (TGF-β) family. This review focuses on the roles of TGF-β family signaling in mesenchymal lineage commitment and differentiation into osteoblasts, chondrocytes, myoblasts, adipocytes, and tenocytes.We summarize the reported findings of cell culture studies, animal models, and interactions with other signaling pathways and highlight how aberrations in TGF-β family signaling can drive human disease by affecting mesenchymal differentiation.

Original languageEnglish (US)
Article numbera022202
JournalCold Spring Harbor Perspectives in Biology
Volume10
Issue number5
DOIs
StatePublished - May 2018
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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