The β-thymosin enigma

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Actin dynamics in nonmuscle cells is controlled by the availability of actin nucleating sites and actin monomers. Thymosin β-4 (Tβ-4) has been implicated in modulating the availability of actin monomers in a large variety of cells. It together with actin nucleating, severing, and uncapping proteins, harnesses the intrinsic dynamic properties of actin to regulate the actin polymerization response in cells. Overexpression or addition of exogenous Tβ-4 or its homolog, Tβ-10, alters the actin cytoskeleton, and has multiple effects on cellular functions related to motility. Some of these effects are consistent with β-thymosins functioning exclusively as monomer-binding proteins, while others are not. Therefore, the complex pleiotropic effects of β-thymosin in cells may be due to direct and indirect effects on the actin cytoskeleton, as well as modulation of signaling pathways that will impact the cytoskeleton and a variety of cell functions.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages45-55
Number of pages11
Volume1112
DOIs
StatePublished - Sep 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1112
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Thymosin
Actins
Actin Cytoskeleton
Monomers
Availability
Cytoskeleton
Polymerization
Carrier Proteins
Modulation

Keywords

  • Actin
  • Cell migration
  • Integrin signaling
  • Thymosinβ-10
  • Thymosinβ-4

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Hui, Q. S., & Yin, H. L. (2007). The β-thymosin enigma. In Annals of the New York Academy of Sciences (Vol. 1112, pp. 45-55). (Annals of the New York Academy of Sciences; Vol. 1112). https://doi.org/10.1196/annals.1415.021

The β-thymosin enigma. / Hui, Qiao Sun; Yin, Helen L.

Annals of the New York Academy of Sciences. Vol. 1112 2007. p. 45-55 (Annals of the New York Academy of Sciences; Vol. 1112).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Hui, QS & Yin, HL 2007, The β-thymosin enigma. in Annals of the New York Academy of Sciences. vol. 1112, Annals of the New York Academy of Sciences, vol. 1112, pp. 45-55. https://doi.org/10.1196/annals.1415.021
Hui QS, Yin HL. The β-thymosin enigma. In Annals of the New York Academy of Sciences. Vol. 1112. 2007. p. 45-55. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1415.021
Hui, Qiao Sun ; Yin, Helen L. / The β-thymosin enigma. Annals of the New York Academy of Sciences. Vol. 1112 2007. pp. 45-55 (Annals of the New York Academy of Sciences).
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