The activated keratinocyte: Up regulation of cell adhesion and migration during wound healing

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Abstract

Keratinocytes play different roles in normal and wounded skin. In normal skin, these cells are specialized for differentiation. In wounded skin, they are specialized for migration. This article discusses the idea that migratory-competent keratinocytes are ''activated.'' Changes that characterize the activation process include increased cell attachment, spreading, focal adhesion formation, and migration. In part, these changes can be explained by enhanced expression of α5 integrin subunits and reorganization of β1 integrin subunits.

Original languageEnglish (US)
JournalJournal of Trauma
Volume30
Issue number12 SUPPL.
StatePublished - 1990

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Keratinocytes
Cell Adhesion
Wound Healing
Cell Movement
Up-Regulation
Integrins
Skin
Focal Adhesions
Cell Differentiation

ASJC Scopus subject areas

  • Surgery

Cite this

The activated keratinocyte : Up regulation of cell adhesion and migration during wound healing. / Grinnell, F.

In: Journal of Trauma, Vol. 30, No. 12 SUPPL., 1990.

Research output: Contribution to journalArticle

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