The activated keratinocyte: Up regulation of cell adhesion and migration during wound healing

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Keratinocytes play different roles in normal and wounded skin. In normal skin, these cells are specialized for differentiation. In wounded skin, they are specialized for migration. This article discusses the idea that migratory-competent keratinocytes are “activated.” Changes that characterize the activation process include increased cell attachment, spreading, focal adhesion formation, and migration. In part, these changes can be explained by enhanced expression of α5 integrin subunits and reorganization of β1 integrin subunits.

Original languageEnglish (US)
Pages (from-to)S144-S149
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume30
Issue number12
StatePublished - Dec 1990

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine

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