The advent of highly selective inhibitors of cyclooxygenase - A review

Byron Cryer; Andre Dubois

doi:10.1016/S0090-6980(98)00064-1

The advent of highly selective inhibitors of cyclooxygenase - A review

Byron Cryer, Andre Dubois

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Cyclooxygenase (COX) exists in two isoforms, COX-1 and COX-2. COX-1 is present and is constitutively expressed in most cells and tissues, whereas COX-2 is felt to principally mediate inflammation. However, this distinction appears to be challenged by recent observations. This review addresses the roles of COX-1 and COX-2 isoforms in physiologic and pathophysiologic states and reviews potential therapeutic roles for selective COX inhibitors.

Original language	English (US)
Pages (from-to)	341-361
Number of pages	21
Journal	Prostaglandins and Other Lipid Mediators
Volume	56
Issue number	5-6
DOIs	https://doi.org/10.1016/S0090-6980(98)00064-1
State	Published - 1998

Keywords

Cyclooxygenase 1
Cyclooxygenase 2
Gastro-intestinal tract

ASJC Scopus subject areas

Biochemistry
Physiology
Pharmacology
Cell Biology

Access to Document

10.1016/S0090-6980(98)00064-1

Cite this

@article{ed6f1b329b9c439c8b07684e90e1912d,

title = "The advent of highly selective inhibitors of cyclooxygenase - A review",

abstract = "Cyclooxygenase (COX) exists in two isoforms, COX-1 and COX-2. COX-1 is present and is constitutively expressed in most cells and tissues, whereas COX-2 is felt to principally mediate inflammation. However, this distinction appears to be challenged by recent observations. This review addresses the roles of COX-1 and COX-2 isoforms in physiologic and pathophysiologic states and reviews potential therapeutic roles for selective COX inhibitors.",

keywords = "Cyclooxygenase 1, Cyclooxygenase 2, Gastro-intestinal tract",

author = "Byron Cryer and Andre Dubois",

year = "1998",

doi = "10.1016/S0090-6980(98)00064-1",

language = "English (US)",

volume = "56",

pages = "341--361",

journal = "Prostaglandins and Other Lipid Mediators",

issn = "0090-6980",

publisher = "Elsevier BV",

number = "5-6",

}

TY - JOUR

T1 - The advent of highly selective inhibitors of cyclooxygenase - A review

AU - Cryer, Byron

AU - Dubois, Andre

PY - 1998

Y1 - 1998

N2 - Cyclooxygenase (COX) exists in two isoforms, COX-1 and COX-2. COX-1 is present and is constitutively expressed in most cells and tissues, whereas COX-2 is felt to principally mediate inflammation. However, this distinction appears to be challenged by recent observations. This review addresses the roles of COX-1 and COX-2 isoforms in physiologic and pathophysiologic states and reviews potential therapeutic roles for selective COX inhibitors.

AB - Cyclooxygenase (COX) exists in two isoforms, COX-1 and COX-2. COX-1 is present and is constitutively expressed in most cells and tissues, whereas COX-2 is felt to principally mediate inflammation. However, this distinction appears to be challenged by recent observations. This review addresses the roles of COX-1 and COX-2 isoforms in physiologic and pathophysiologic states and reviews potential therapeutic roles for selective COX inhibitors.

KW - Cyclooxygenase 1

KW - Cyclooxygenase 2

KW - Gastro-intestinal tract

UR - http://www.scopus.com/inward/record.url?scp=0032464008&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032464008&partnerID=8YFLogxK

U2 - 10.1016/S0090-6980(98)00064-1

DO - 10.1016/S0090-6980(98)00064-1

M3 - Article

C2 - 9990677

AN - SCOPUS:0032464008

SN - 0090-6980

VL - 56

SP - 341

EP - 361

JO - Prostaglandins and Other Lipid Mediators

JF - Prostaglandins and Other Lipid Mediators

IS - 5-6

ER -

The advent of highly selective inhibitors of cyclooxygenase - A review

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this