The advent of highly selective inhibitors of cyclooxygenase - A review

Byron Cryer, Andre Dubois

Research output: Contribution to journalArticle

80 Scopus citations

Abstract

Cyclooxygenase (COX) exists in two isoforms, COX-1 and COX-2. COX-1 is present and is constitutively expressed in most cells and tissues, whereas COX-2 is felt to principally mediate inflammation. However, this distinction appears to be challenged by recent observations. This review addresses the roles of COX-1 and COX-2 isoforms in physiologic and pathophysiologic states and reviews potential therapeutic roles for selective COX inhibitors.

Original languageEnglish (US)
Pages (from-to)341-361
Number of pages21
JournalProstaglandins and Other Lipid Mediators
Volume56
Issue number5-6
DOIs
StatePublished - Jan 1 1998

Keywords

  • Cyclooxygenase 1
  • Cyclooxygenase 2
  • Gastro-intestinal tract

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

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