The androgen receptor in the fetal epididymis is similar to that in the mature rabbit.

F. W. George, K. G. Peterson, P. A. Frenkel, J. D. Wilson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To provide insight into the mechanism of wolffian duct virilization the androgen receptor has been characterized in pooled epididymal tissue from Day 27 rabbit embryos. Although the receptor is present at levels about a tenth that of other androgen target tissues in rabbit embryos, it appears to be a typical androgen receptor in regard to sedimentation characteristics and preferential binding of 5 alpha-dihydrotestosterone over testosterone. Thus, the mechanism by which testosterone virilizes the wolffian duct cannot be explained by unique binding characteristics of the androgen receptor in tissues derived from the wolffian ducts.

Original languageEnglish (US)
Pages (from-to)500-503
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume188
Issue number4
StatePublished - Sep 1988

Fingerprint

Wolffian Ducts
Epididymis
Androgen Receptors
Ducts
Tissue
Rabbits
Testosterone
Embryonic Structures
Virilism
Dihydrotestosterone
Sedimentation
Androgens

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The androgen receptor in the fetal epididymis is similar to that in the mature rabbit. / George, F. W.; Peterson, K. G.; Frenkel, P. A.; Wilson, J. D.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 188, No. 4, 09.1988, p. 500-503.

Research output: Contribution to journalArticle

George, F. W. ; Peterson, K. G. ; Frenkel, P. A. ; Wilson, J. D. / The androgen receptor in the fetal epididymis is similar to that in the mature rabbit. In: Proceedings of the Society for Experimental Biology and Medicine. 1988 ; Vol. 188, No. 4. pp. 500-503.
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