The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120: Genetic variability and subtypes

Xiao Nan Dong; Yi Wu; Jian Ying; Ying Hua Chen

doi:10.1016/j.imlet.2005.04.008

The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120: Genetic variability and subtypes

Xiao Nan Dong, Yi Wu, Jian Ying, Ying Hua Chen

Internal Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

V3 loop on HIV-1 gp120 is tightly correlated with syncytium formation, coreceptor usage, virus infectivity and antibody neutralization. The antigenic tip GPGRAFY with its flanking sequence has a conserved secondary structure, and is the target of neutralizing antibodies. We analyzed its genetic variability in 30096 M-group isolates and 269 O-group isolates. Subtype-related restricted mutations were observed, which could help to identify subtypes.

Original language	English (US)
Pages (from-to)	112-114
Number of pages	3
Journal	Immunology Letters
Volume	101
Issue number	1
DOIs	https://doi.org/10.1016/j.imlet.2005.04.008
State	Published - Oct 15 2005

Keywords

GPGRAFY
Genetic variability
Restricted mutation
Subtype
V3

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.imlet.2005.04.008

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abstract = "V3 loop on HIV-1 gp120 is tightly correlated with syncytium formation, coreceptor usage, virus infectivity and antibody neutralization. The antigenic tip GPGRAFY with its flanking sequence has a conserved secondary structure, and is the target of neutralizing antibodies. We analyzed its genetic variability in 30096 M-group isolates and 269 O-group isolates. Subtype-related restricted mutations were observed, which could help to identify subtypes.",

keywords = "GPGRAFY, Genetic variability, Restricted mutation, Subtype, V3",

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AU - Dong, Xiao Nan

AU - Wu, Yi

AU - Ying, Jian

AU - Chen, Ying Hua

PY - 2005/10/15

Y1 - 2005/10/15

N2 - V3 loop on HIV-1 gp120 is tightly correlated with syncytium formation, coreceptor usage, virus infectivity and antibody neutralization. The antigenic tip GPGRAFY with its flanking sequence has a conserved secondary structure, and is the target of neutralizing antibodies. We analyzed its genetic variability in 30096 M-group isolates and 269 O-group isolates. Subtype-related restricted mutations were observed, which could help to identify subtypes.

AB - V3 loop on HIV-1 gp120 is tightly correlated with syncytium formation, coreceptor usage, virus infectivity and antibody neutralization. The antigenic tip GPGRAFY with its flanking sequence has a conserved secondary structure, and is the target of neutralizing antibodies. We analyzed its genetic variability in 30096 M-group isolates and 269 O-group isolates. Subtype-related restricted mutations were observed, which could help to identify subtypes.

KW - GPGRAFY

KW - Genetic variability

KW - Restricted mutation

KW - Subtype

KW - V3

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The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120: Genetic variability and subtypes

Abstract

Keywords

ASJC Scopus subject areas

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