The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120: Genetic variability and subtypes

Xiao Nan Dong, Yi Wu, Jian Ying, Ying Hua Chen

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

V3 loop on HIV-1 gp120 is tightly correlated with syncytium formation, coreceptor usage, virus infectivity and antibody neutralization. The antigenic tip GPGRAFY with its flanking sequence has a conserved secondary structure, and is the target of neutralizing antibodies. We analyzed its genetic variability in 30096 M-group isolates and 269 O-group isolates. Subtype-related restricted mutations were observed, which could help to identify subtypes.

Original languageEnglish (US)
Pages (from-to)112-114
Number of pages3
JournalImmunology Letters
Volume101
Issue number1
DOIs
StatePublished - Oct 15 2005

Keywords

  • Genetic variability
  • GPGRAFY
  • Restricted mutation
  • Subtype
  • V3

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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