The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120: Genetic variability and subtypes

Xiao Nan Dong, Yi Wu, Jian Ying, Ying Hua Chen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

V3 loop on HIV-1 gp120 is tightly correlated with syncytium formation, coreceptor usage, virus infectivity and antibody neutralization. The antigenic tip GPGRAFY with its flanking sequence has a conserved secondary structure, and is the target of neutralizing antibodies. We analyzed its genetic variability in 30096 M-group isolates and 269 O-group isolates. Subtype-related restricted mutations were observed, which could help to identify subtypes.

Original languageEnglish (US)
Pages (from-to)112-114
Number of pages3
JournalImmunology Letters
Volume101
Issue number1
DOIs
StatePublished - Oct 15 2005

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Giant Cells
Neutralizing Antibodies
HIV-1
Viruses
Mutation
Antibodies

Keywords

  • Genetic variability
  • GPGRAFY
  • Restricted mutation
  • Subtype
  • V3

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120 : Genetic variability and subtypes. / Dong, Xiao Nan; Wu, Yi; Ying, Jian; Chen, Ying Hua.

In: Immunology Letters, Vol. 101, No. 1, 15.10.2005, p. 112-114.

Research output: Contribution to journalArticle

Dong, Xiao Nan ; Wu, Yi ; Ying, Jian ; Chen, Ying Hua. / The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120 : Genetic variability and subtypes. In: Immunology Letters. 2005 ; Vol. 101, No. 1. pp. 112-114.
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