The Aplysia FMRFamide Gene Encodes Sequences Related to Mammalian Brain Peptides

R. Taussig, R. H. Scheller

Research output: Contribution to journalArticle

91 Scopus citations

Abstract

We have characterized a precursor protein which gives rise to the neuropeptide Phe-Met-Arg-Phe-amide (FMRFamide) by determining the nucleotide sequence of a genomic and five cDNA clones. The 597-aminoacid protein contains 28 copies of the tetrapeptide FMRFamide, a single Phe-Leu-Arg-Phe-amide (FLRFamide), and other sequences flanked by paired basic residues, some of which have homologies to mammalian brain peptides. The data presented suggest the genes encoding pro-opiomelanocortin, pre-pro-enkephalin, and the hypothalamic releasing factor, cortico-releasing factor (CRF), arose from a common ancestral gene.

Original languageEnglish (US)
Pages (from-to)453-461
Number of pages9
JournalDNA
Volume5
Issue number6
DOIs
StatePublished - Dec 1986

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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