The assembly of lipid droplets and their roles in challenged cells

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Cytoplasmic lipid droplets are important organelles in nearly every eukaryotic and some prokaryotic cells. Storing and providing energy is their main function, but they do not work in isolation. They respond to stimuli initiated either on the cell surface or in the cytoplasm as conditions change. Cellular stresses such as starvation and invasion are internal insults that evoke changes in droplet metabolism and dynamics. This review will first outline lipid droplet assembly and then discuss how droplets respond to stress and in particular nutrient starvation. Finally, the role of droplets in viral and microbial invasion will be presented, where an unresolved issue is whether changes in droplet abundance promote the invader, defend the host, to try to do both. The challenges of stress and infection are often accompanied by changes in physical contacts between droplets and other organelles. How these changes may result in improving cellular physiology, an ongoing focus in the field, is discussed.

Original languageEnglish (US)
Article numbere98947
JournalEMBO Journal
Volume37
Issue number12
DOIs
StatePublished - Jun 15 2018

Fingerprint

Starvation
Organelles
Prokaryotic Cells
Lipids
Cytoplasm
Food
Infection
Physiology
Lipid Droplets
Metabolism
Contacts (fluid mechanics)
Nutrients

Keywords

  • cellular stresses
  • lipid droplet assembly
  • metabolism
  • microbial invasion
  • starvation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

The assembly of lipid droplets and their roles in challenged cells. / Henne, W. Mike; Reese, Michael L.; Goodman, Joel M.

In: EMBO Journal, Vol. 37, No. 12, e98947, 15.06.2018.

Research output: Contribution to journalReview article

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