Abstract
Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC.
| Original language | English (US) |
|---|---|
| Article number | e1311827 |
| Journal | Molecular and Cellular Oncology |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - May 4 2017 |
| Externally published | Yes |
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Keywords
- ATX
- chemoprevention
- cirrhosis
- fibrosis
- HCC
- hepatocellular carcinoma
- LPA
- LPAR1
- NASH
- non-alcoholic steatohepatitis
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research
Cite this
The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer. / Erstad, Derek J.; Tager, Andrew M.; Hoshida, Yujin; Fuchs, Bryan C.
In: Molecular and Cellular Oncology, Vol. 4, No. 3, e1311827, 04.05.2017.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The autotaxin-lysophosphatidic acid pathway emerges as a therapeutic target to prevent liver cancer
AU - Erstad, Derek J.
AU - Tager, Andrew M.
AU - Hoshida, Yujin
AU - Fuchs, Bryan C.
PY - 2017/5/4
Y1 - 2017/5/4
N2 - Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC.
AB - Using transcriptome meta-analysis, we recently identified the autotaxin (ATX)-lysophosphatidic acid (LPA) pathway as a regulator of hepatocellular carcinoma (HCC) risk in human cirrhosis patients. Pharmacological targeting of this pathway reduced fibrosis progression and HCC development in animals, identifying ATX-LPA signaling as a novel chemoprevention strategy for cirrhosis and HCC.
KW - ATX
KW - chemoprevention
KW - cirrhosis
KW - fibrosis
KW - HCC
KW - hepatocellular carcinoma
KW - LPA
KW - LPAR1
KW - NASH
KW - non-alcoholic steatohepatitis
UR - http://www.scopus.com/inward/record.url?scp=85037622026&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85037622026&partnerID=8YFLogxK
U2 - 10.1080/23723556.2017.1311827
DO - 10.1080/23723556.2017.1311827
M3 - Article
C2 - 28616586
AN - SCOPUS:85037622026
VL - 4
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
SN - 2372-3556
IS - 3
M1 - e1311827
ER -