The cellular basis of adjuvant arthritis. II. Characterization of the cells mediating passive transfer

Joel D. Taurog, Gregory P. Sandberg, Maren L. Mahowald

Research output: Contribution to journalArticle

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Abstract

It has previously been reported that lymph node or spleen cells from rats with adjuvantinduced arthritis can transfer the disease to normal recipients after being cultured with concanavalin A (Con A). In this report, it is shown that a subpopulation of cells that (1) lack surface Ig and the antigen reactive with the monoclonal antibody OX8, (2) are largely nonadherent and esterase negative, and (3) are predominantly marked by the monoclonal antibody W3/25 can transfer arthritis after stimulation with Con A. Adjuvant-sensitized lymph node or spleen cells stimulated with Con A but not PHA transfer arthritis, and this difference correlates with relatively higher levels of interleukin 2 secretion by Con A-stimulated cells. A synthetic adjuvant, CP-20961, a substituted propanediamine, induces arthritis that is passively transferable under the same conditions as arthritis induced by classical mycobacterium-containing adjuvant. The data support the hypothesis that adjuvant inoculation in the rat results in the induction of a unique subpopulation of T cells that initiate the inflammatory joint disease.

Original languageEnglish (US)
Pages (from-to)198-204
Number of pages7
JournalCellular Immunology
Volume80
Issue number1
DOIs
StatePublished - 1983

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Experimental Arthritis
Arthritis
Concanavalin A
Spleen
Lymph Nodes
Monoclonal Antibodies
Carboxylesterase
Joint Diseases
Surface Antigens
Mycobacterium
Interleukin-2
T-Lymphocytes

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

The cellular basis of adjuvant arthritis. II. Characterization of the cells mediating passive transfer. / Taurog, Joel D.; Sandberg, Gregory P.; Mahowald, Maren L.

In: Cellular Immunology, Vol. 80, No. 1, 1983, p. 198-204.

Research output: Contribution to journalArticle

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