The circadian gene Clock is restricted to the anterior neural plate early in development and is regulated by the neural inducer noggin and the transcription factor Otx2

Carla B. Green, Antony J. Durston, Richard Morgan

Research output: Contribution to journalArticle

18 Scopus citations


The circadian cycle is a simple, universal molecular mechanism for imposing cyclical control on cellular processes. Here we have examined the regulation of one of the key circadian genes, Clock, in early Xenopus development. We find that the expression of Clock is dependent on developmental stage, not on time per se, and is mostly restricted to the anterior neural plate. It's expression can be induced by the secreted polypeptide noggin, and subsequently upregulated by Otx2, a transcription factor required for the determination of anterior fate.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalMechanisms of Development
Issue number1-2
StatePublished - Mar 14 2001



  • Anterior
  • Circadian
  • Clock
  • Early development
  • Neural plate
  • Otx2
  • noggin

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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