Abstract
The circadian cycle is a simple, universal molecular mechanism for imposing cyclical control on cellular processes. Here we have examined the regulation of one of the key circadian genes, Clock, in early Xenopus development. We find that the expression of Clock is dependent on developmental stage, not on time per se, and is mostly restricted to the anterior neural plate. It's expression can be induced by the secreted polypeptide noggin, and subsequently upregulated by Otx2, a transcription factor required for the determination of anterior fate.
Original language | English (US) |
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Pages (from-to) | 105-110 |
Number of pages | 6 |
Journal | Mechanisms of Development |
Volume | 101 |
Issue number | 1-2 |
DOIs | |
State | Published - 2001 |
Keywords
- Anterior
- Circadian
- Clock
- Early development
- Neural plate
- Otx2
- noggin
ASJC Scopus subject areas
- Embryology
- Developmental Biology