The conception of the ABCD study: From substance use to a broad NIH collaboration

Nora D. Volkow; George F. Koob; Robert T. Croyle; Diana W. Bianchi; Joshua A. Gordon; Walter J. Koroshetz; Eliseo J. Pérez-Stable; William T. Riley; Michele H. Bloch; Kevin Conway; Bethany G. Deeds; Gayathri J. Dowling; Steven Grant; Katia D. Howlett; John A. Matochik; Glen D. Morgan; Margaret M. Murray; Antonio Noronha; Catherine Y. Spong; Eric M. Wargo; Kenneth R. Warren; Susan R.B. Weiss

doi:10.1016/j.dcn.2017.10.002

The conception of the ABCD study: From substance use to a broad NIH collaboration

Nora D. Volkow, George F. Koob, Robert T. Croyle, Diana W. Bianchi, Joshua A. Gordon, Walter J. Koroshetz, Eliseo J. Pérez-Stable, William T. Riley, Michele H. Bloch, Kevin Conway, Bethany G. Deeds, Gayathri J. Dowling, Steven Grant, Katia D. Howlett, John A. Matochik, Glen D. Morgan, Margaret M. Murray, Antonio Noronha, Catherine Y. Spong, Eric M. WargoKenneth R. Warren, Susan R.B. Weiss

Research output: Contribution to journal › Review article › peer-review

416 Scopus citations

Abstract

Adolescence is a time of dramatic changes in brain structure and function, and the adolescent brain is highly susceptible to being altered by experiences like substance use. However, there is much we have yet to learn about how these experiences influence brain development, how they promote or interfere with later health outcomes, or even what healthy brain development looks like. A large longitudinal study beginning in early adolescence could help us understand the normal variability in adolescent brain and cognitive development and tease apart the many factors that influence it. Recent advances in neuroimaging, informatics, and genetics technologies have made it feasible to conduct a study of sufficient size and scope to answer many outstanding questions. At the same time, several Institutes across the NIH recognized the value of collaborating in such a project because of its ability to address the role of biological, environmental, and behavioral factors like gender, pubertal hormones, sports participation, and social/economic disparities on brain development as well as their association with the emergence and progression of substance use and mental illness including suicide risk. Thus, the Adolescent Brain Cognitive Development study was created to answer the most pressing public health questions of our day.

Original language	English (US)
Pages (from-to)	4-7
Number of pages	4
Journal	Developmental Cognitive Neuroscience
Volume	32
DOIs	https://doi.org/10.1016/j.dcn.2017.10.002
State	Published - Aug 2018
Externally published	Yes

Keywords

Adolescent
Brain development
Longitudinal
Mental health
Neuroimaging
Substance use

ASJC Scopus subject areas

Cognitive Neuroscience

Access to Document

10.1016/j.dcn.2017.10.002

Cite this

Volkow, N. D., Koob, G. F., Croyle, R. T., Bianchi, D. W., Gordon, J. A., Koroshetz, W. J., Pérez-Stable, E. J., Riley, W. T., Bloch, M. H., Conway, K., Deeds, B. G., Dowling, G. J., Grant, S., Howlett, K. D., Matochik, J. A., Morgan, G. D., Murray, M. M., Noronha, A., Spong, C. Y., ... Weiss, S. R. B. (2018). The conception of the ABCD study: From substance use to a broad NIH collaboration. Developmental Cognitive Neuroscience, 32, 4-7. https://doi.org/10.1016/j.dcn.2017.10.002

Volkow, ND, Koob, GF, Croyle, RT, Bianchi, DW, Gordon, JA, Koroshetz, WJ, Pérez-Stable, EJ, Riley, WT, Bloch, MH, Conway, K, Deeds, BG, Dowling, GJ, Grant, S, Howlett, KD, Matochik, JA, Morgan, GD, Murray, MM, Noronha, A, Spong, CY, Wargo, EM, Warren, KR & Weiss, SRB 2018, 'The conception of the ABCD study: From substance use to a broad NIH collaboration', Developmental Cognitive Neuroscience, vol. 32, pp. 4-7. https://doi.org/10.1016/j.dcn.2017.10.002

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title = "The conception of the ABCD study: From substance use to a broad NIH collaboration",

abstract = "Adolescence is a time of dramatic changes in brain structure and function, and the adolescent brain is highly susceptible to being altered by experiences like substance use. However, there is much we have yet to learn about how these experiences influence brain development, how they promote or interfere with later health outcomes, or even what healthy brain development looks like. A large longitudinal study beginning in early adolescence could help us understand the normal variability in adolescent brain and cognitive development and tease apart the many factors that influence it. Recent advances in neuroimaging, informatics, and genetics technologies have made it feasible to conduct a study of sufficient size and scope to answer many outstanding questions. At the same time, several Institutes across the NIH recognized the value of collaborating in such a project because of its ability to address the role of biological, environmental, and behavioral factors like gender, pubertal hormones, sports participation, and social/economic disparities on brain development as well as their association with the emergence and progression of substance use and mental illness including suicide risk. Thus, the Adolescent Brain Cognitive Development study was created to answer the most pressing public health questions of our day.",

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doi = "10.1016/j.dcn.2017.10.002",

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AU - Gordon, Joshua A.

AU - Koroshetz, Walter J.

AU - Pérez-Stable, Eliseo J.

AU - Riley, William T.

AU - Bloch, Michele H.

AU - Conway, Kevin

AU - Deeds, Bethany G.

AU - Dowling, Gayathri J.

AU - Grant, Steven

AU - Howlett, Katia D.

AU - Matochik, John A.

AU - Morgan, Glen D.

AU - Murray, Margaret M.

AU - Noronha, Antonio

AU - Spong, Catherine Y.

AU - Wargo, Eric M.

AU - Warren, Kenneth R.

AU - Weiss, Susan R.B.

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The conception of the ABCD study: From substance use to a broad NIH collaboration

Abstract

Keywords

ASJC Scopus subject areas

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