The coordinated biology and signaling partners of Ral G-proteins

Brian O. Bodemann, Michael A. White

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The Ras-like (Ral) guanyl nucleotide-binding proteins, RALA and RALB, are highly similar proteins, which occupy sometimes overlapping, convergent, or divergent roles in regulating distinct biological processes. As downstream signaling partners of oncogenic Ras, these two proteins have been described to be hyper-activated in tumors to support aberrant biology during oncogenic transformation. To regulate a varied collection of normal and oncogenic biological processes, Ral G-proteins engage with six upstream RalGEF proteins, two upstream RalGAP complexes, and at least five distinct downstream effector pathways. Further specification of Ral signaling activity is ascribed to distinct posttranslational modifications of RALA, RALB, their upstream regulators, and their effectors. Emerging signaling paradigms within Ral signaling networks provide important insight into the signaling architectures exhibited by not only Ral G-proteins but also the wider range of Ras superfamily small G-proteins as well.

Original languageEnglish (US)
Title of host publicationRas Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling
PublisherSpringer-Verlag Wien
Pages257-279
Number of pages23
Volume9783709118061
ISBN (Print)9783709118061, 3709118050, 9783709118054
DOIs
StatePublished - May 1 2014

Fingerprint

Biological Phenomena
GTP-Binding Proteins
ras Proteins
Monomeric GTP-Binding Proteins
Post Translational Protein Processing
Carrier Proteins
Proteins
Nucleotides
Neoplasms
Tumors
Specifications

Keywords

  • Autophagy
  • Exo84
  • Exocyst
  • Innate immunity
  • Oncogenes
  • RalA
  • RalB
  • RalBP1
  • RalGAP
  • RalGEF
  • Ras family G-proteins
  • Sec5

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bodemann, B. O., & White, M. A. (2014). The coordinated biology and signaling partners of Ral G-proteins. In Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling (Vol. 9783709118061, pp. 257-279). Springer-Verlag Wien. https://doi.org/10.1007/978-3-7091-1806-1_12

The coordinated biology and signaling partners of Ral G-proteins. / Bodemann, Brian O.; White, Michael A.

Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling. Vol. 9783709118061 Springer-Verlag Wien, 2014. p. 257-279.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bodemann, BO & White, MA 2014, The coordinated biology and signaling partners of Ral G-proteins. in Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling. vol. 9783709118061, Springer-Verlag Wien, pp. 257-279. https://doi.org/10.1007/978-3-7091-1806-1_12
Bodemann BO, White MA. The coordinated biology and signaling partners of Ral G-proteins. In Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling. Vol. 9783709118061. Springer-Verlag Wien. 2014. p. 257-279 https://doi.org/10.1007/978-3-7091-1806-1_12
Bodemann, Brian O. ; White, Michael A. / The coordinated biology and signaling partners of Ral G-proteins. Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling. Vol. 9783709118061 Springer-Verlag Wien, 2014. pp. 257-279
@inbook{8d7c141cdf9e43c39ac32ee408a39a91,
title = "The coordinated biology and signaling partners of Ral G-proteins",
abstract = "The Ras-like (Ral) guanyl nucleotide-binding proteins, RALA and RALB, are highly similar proteins, which occupy sometimes overlapping, convergent, or divergent roles in regulating distinct biological processes. As downstream signaling partners of oncogenic Ras, these two proteins have been described to be hyper-activated in tumors to support aberrant biology during oncogenic transformation. To regulate a varied collection of normal and oncogenic biological processes, Ral G-proteins engage with six upstream RalGEF proteins, two upstream RalGAP complexes, and at least five distinct downstream effector pathways. Further specification of Ral signaling activity is ascribed to distinct posttranslational modifications of RALA, RALB, their upstream regulators, and their effectors. Emerging signaling paradigms within Ral signaling networks provide important insight into the signaling architectures exhibited by not only Ral G-proteins but also the wider range of Ras superfamily small G-proteins as well.",
keywords = "Autophagy, Exo84, Exocyst, Innate immunity, Oncogenes, RalA, RalB, RalBP1, RalGAP, RalGEF, Ras family G-proteins, Sec5",
author = "Bodemann, {Brian O.} and White, {Michael A.}",
year = "2014",
month = "5",
day = "1",
doi = "10.1007/978-3-7091-1806-1_12",
language = "English (US)",
isbn = "9783709118061",
volume = "9783709118061",
pages = "257--279",
booktitle = "Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling",
publisher = "Springer-Verlag Wien",

}

TY - CHAP

T1 - The coordinated biology and signaling partners of Ral G-proteins

AU - Bodemann, Brian O.

AU - White, Michael A.

PY - 2014/5/1

Y1 - 2014/5/1

N2 - The Ras-like (Ral) guanyl nucleotide-binding proteins, RALA and RALB, are highly similar proteins, which occupy sometimes overlapping, convergent, or divergent roles in regulating distinct biological processes. As downstream signaling partners of oncogenic Ras, these two proteins have been described to be hyper-activated in tumors to support aberrant biology during oncogenic transformation. To regulate a varied collection of normal and oncogenic biological processes, Ral G-proteins engage with six upstream RalGEF proteins, two upstream RalGAP complexes, and at least five distinct downstream effector pathways. Further specification of Ral signaling activity is ascribed to distinct posttranslational modifications of RALA, RALB, their upstream regulators, and their effectors. Emerging signaling paradigms within Ral signaling networks provide important insight into the signaling architectures exhibited by not only Ral G-proteins but also the wider range of Ras superfamily small G-proteins as well.

AB - The Ras-like (Ral) guanyl nucleotide-binding proteins, RALA and RALB, are highly similar proteins, which occupy sometimes overlapping, convergent, or divergent roles in regulating distinct biological processes. As downstream signaling partners of oncogenic Ras, these two proteins have been described to be hyper-activated in tumors to support aberrant biology during oncogenic transformation. To regulate a varied collection of normal and oncogenic biological processes, Ral G-proteins engage with six upstream RalGEF proteins, two upstream RalGAP complexes, and at least five distinct downstream effector pathways. Further specification of Ral signaling activity is ascribed to distinct posttranslational modifications of RALA, RALB, their upstream regulators, and their effectors. Emerging signaling paradigms within Ral signaling networks provide important insight into the signaling architectures exhibited by not only Ral G-proteins but also the wider range of Ras superfamily small G-proteins as well.

KW - Autophagy

KW - Exo84

KW - Exocyst

KW - Innate immunity

KW - Oncogenes

KW - RalA

KW - RalB

KW - RalBP1

KW - RalGAP

KW - RalGEF

KW - Ras family G-proteins

KW - Sec5

UR - http://www.scopus.com/inward/record.url?scp=84930847400&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930847400&partnerID=8YFLogxK

U2 - 10.1007/978-3-7091-1806-1_12

DO - 10.1007/978-3-7091-1806-1_12

M3 - Chapter

SN - 9783709118061

SN - 3709118050

SN - 9783709118054

VL - 9783709118061

SP - 257

EP - 279

BT - Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling

PB - Springer-Verlag Wien

ER -