The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the women's health initiative

Diana R. Kerwin, Yinghua Zhang, Jane Morley Kotchen, Mark A. Espeland, Linda Van Horn, Kathleen M. McTigue, Jennifer G. Robinson, Lynda Powell, Charles Kooperberg, Laura H. Coker, Raymond Hoffmann

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objectives: To determine whether body mass index (BMI) is independently associated with cognitive function in postmenopausal women and the relationship between body fat distribution as estimated by waist-hip ratio (WHR). Design: Cross-sectional data analysis. Setting: Baseline data from the Women's Health Initiative (WHI) hormone trials. Participants: Eight thousand seven hundred forty-five postmenopausal women aged 65 to 79 free of clinical evidence of dementia who completed the baseline evaluation in the WHI hormone trials. Measurements: Participants completed a Modified Mini-Mental State Examination (3MSE), health and lifestyle questionnaires, and standardized measurements of height, weight, body circumference, and blood pressure. Statistical analysis was performed of associations between 3MSE score, BMI, and WHR after controlling for known confounders. Results: With the exception of smoking and exercise, vascular disease risk factors, including hypertension, waist measurement, heart disease, and diabetes mellitus, were significantly associated with 3MSE score and were included as covariables in subsequent analyses. BMI was inversely related to 3MSE score; for every 1-unit increase in BMI, 3MSE score decreased 0.988 points (P<.001) after adjusting for age, education, and vascular disease risk factors. BMI had the most pronounced association with poorer cognitive functioning scores in women with smaller waist measurements. In women with the highest WHR, cognitive scores increased with BMI. Conclusion: Higher BMI was associated with poorer cognitive function in women with smaller WHR. Higher WHR, estimating central fat mass, was associated with higher cognitive function in this cross-sectional study. Further research is needed to clarify the mechanism for this association.

Original languageEnglish (US)
Pages (from-to)1427-1432
Number of pages6
JournalJournal of the American Geriatrics Society
Volume58
Issue number8
DOIs
StatePublished - Aug 1 2010

Fingerprint

Waist-Hip Ratio
Women's Health
Body Mass Index
Cognition
Vascular Diseases
Cross-Sectional Studies
Hormones
Body Fat Distribution
Body Height
Dementia
Life Style
Heart Diseases
Diabetes Mellitus
Smoking
Fats
Body Weight
Exercise
Blood Pressure
Hypertension
Education

Keywords

  • cognition
  • dementia
  • obesity
  • waist-hip ratio
  • women

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the women's health initiative. / Kerwin, Diana R.; Zhang, Yinghua; Kotchen, Jane Morley; Espeland, Mark A.; Van Horn, Linda; McTigue, Kathleen M.; Robinson, Jennifer G.; Powell, Lynda; Kooperberg, Charles; Coker, Laura H.; Hoffmann, Raymond.

In: Journal of the American Geriatrics Society, Vol. 58, No. 8, 01.08.2010, p. 1427-1432.

Research output: Contribution to journalArticle

Kerwin, Diana R. ; Zhang, Yinghua ; Kotchen, Jane Morley ; Espeland, Mark A. ; Van Horn, Linda ; McTigue, Kathleen M. ; Robinson, Jennifer G. ; Powell, Lynda ; Kooperberg, Charles ; Coker, Laura H. ; Hoffmann, Raymond. / The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the women's health initiative. In: Journal of the American Geriatrics Society. 2010 ; Vol. 58, No. 8. pp. 1427-1432.
@article{ec680b1bfe4d4364a3b69312ded07733,
title = "The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the women's health initiative",
abstract = "Objectives: To determine whether body mass index (BMI) is independently associated with cognitive function in postmenopausal women and the relationship between body fat distribution as estimated by waist-hip ratio (WHR). Design: Cross-sectional data analysis. Setting: Baseline data from the Women's Health Initiative (WHI) hormone trials. Participants: Eight thousand seven hundred forty-five postmenopausal women aged 65 to 79 free of clinical evidence of dementia who completed the baseline evaluation in the WHI hormone trials. Measurements: Participants completed a Modified Mini-Mental State Examination (3MSE), health and lifestyle questionnaires, and standardized measurements of height, weight, body circumference, and blood pressure. Statistical analysis was performed of associations between 3MSE score, BMI, and WHR after controlling for known confounders. Results: With the exception of smoking and exercise, vascular disease risk factors, including hypertension, waist measurement, heart disease, and diabetes mellitus, were significantly associated with 3MSE score and were included as covariables in subsequent analyses. BMI was inversely related to 3MSE score; for every 1-unit increase in BMI, 3MSE score decreased 0.988 points (P<.001) after adjusting for age, education, and vascular disease risk factors. BMI had the most pronounced association with poorer cognitive functioning scores in women with smaller waist measurements. In women with the highest WHR, cognitive scores increased with BMI. Conclusion: Higher BMI was associated with poorer cognitive function in women with smaller WHR. Higher WHR, estimating central fat mass, was associated with higher cognitive function in this cross-sectional study. Further research is needed to clarify the mechanism for this association.",
keywords = "cognition, dementia, obesity, waist-hip ratio, women",
author = "Kerwin, {Diana R.} and Yinghua Zhang and Kotchen, {Jane Morley} and Espeland, {Mark A.} and {Van Horn}, Linda and McTigue, {Kathleen M.} and Robinson, {Jennifer G.} and Lynda Powell and Charles Kooperberg and Coker, {Laura H.} and Raymond Hoffmann",
year = "2010",
month = "8",
day = "1",
doi = "10.1111/j.1532-5415.2010.02969.x",
language = "English (US)",
volume = "58",
pages = "1427--1432",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - The cross-sectional relationship between body mass index, waist-hip ratio, and cognitive performance in postmenopausal women enrolled in the women's health initiative

AU - Kerwin, Diana R.

AU - Zhang, Yinghua

AU - Kotchen, Jane Morley

AU - Espeland, Mark A.

AU - Van Horn, Linda

AU - McTigue, Kathleen M.

AU - Robinson, Jennifer G.

AU - Powell, Lynda

AU - Kooperberg, Charles

AU - Coker, Laura H.

AU - Hoffmann, Raymond

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Objectives: To determine whether body mass index (BMI) is independently associated with cognitive function in postmenopausal women and the relationship between body fat distribution as estimated by waist-hip ratio (WHR). Design: Cross-sectional data analysis. Setting: Baseline data from the Women's Health Initiative (WHI) hormone trials. Participants: Eight thousand seven hundred forty-five postmenopausal women aged 65 to 79 free of clinical evidence of dementia who completed the baseline evaluation in the WHI hormone trials. Measurements: Participants completed a Modified Mini-Mental State Examination (3MSE), health and lifestyle questionnaires, and standardized measurements of height, weight, body circumference, and blood pressure. Statistical analysis was performed of associations between 3MSE score, BMI, and WHR after controlling for known confounders. Results: With the exception of smoking and exercise, vascular disease risk factors, including hypertension, waist measurement, heart disease, and diabetes mellitus, were significantly associated with 3MSE score and were included as covariables in subsequent analyses. BMI was inversely related to 3MSE score; for every 1-unit increase in BMI, 3MSE score decreased 0.988 points (P<.001) after adjusting for age, education, and vascular disease risk factors. BMI had the most pronounced association with poorer cognitive functioning scores in women with smaller waist measurements. In women with the highest WHR, cognitive scores increased with BMI. Conclusion: Higher BMI was associated with poorer cognitive function in women with smaller WHR. Higher WHR, estimating central fat mass, was associated with higher cognitive function in this cross-sectional study. Further research is needed to clarify the mechanism for this association.

AB - Objectives: To determine whether body mass index (BMI) is independently associated with cognitive function in postmenopausal women and the relationship between body fat distribution as estimated by waist-hip ratio (WHR). Design: Cross-sectional data analysis. Setting: Baseline data from the Women's Health Initiative (WHI) hormone trials. Participants: Eight thousand seven hundred forty-five postmenopausal women aged 65 to 79 free of clinical evidence of dementia who completed the baseline evaluation in the WHI hormone trials. Measurements: Participants completed a Modified Mini-Mental State Examination (3MSE), health and lifestyle questionnaires, and standardized measurements of height, weight, body circumference, and blood pressure. Statistical analysis was performed of associations between 3MSE score, BMI, and WHR after controlling for known confounders. Results: With the exception of smoking and exercise, vascular disease risk factors, including hypertension, waist measurement, heart disease, and diabetes mellitus, were significantly associated with 3MSE score and were included as covariables in subsequent analyses. BMI was inversely related to 3MSE score; for every 1-unit increase in BMI, 3MSE score decreased 0.988 points (P<.001) after adjusting for age, education, and vascular disease risk factors. BMI had the most pronounced association with poorer cognitive functioning scores in women with smaller waist measurements. In women with the highest WHR, cognitive scores increased with BMI. Conclusion: Higher BMI was associated with poorer cognitive function in women with smaller WHR. Higher WHR, estimating central fat mass, was associated with higher cognitive function in this cross-sectional study. Further research is needed to clarify the mechanism for this association.

KW - cognition

KW - dementia

KW - obesity

KW - waist-hip ratio

KW - women

UR - http://www.scopus.com/inward/record.url?scp=77955258617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955258617&partnerID=8YFLogxK

U2 - 10.1111/j.1532-5415.2010.02969.x

DO - 10.1111/j.1532-5415.2010.02969.x

M3 - Article

VL - 58

SP - 1427

EP - 1432

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 8

ER -