The Current and Evolving Role of PET in Personalized Management of Lung Cancer

Esther Mena, Anusha Yanamadala, Gang Cheng, Rathan M. Subramaniam

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Using tumor genomic profiling information has revolutionized the landscape of personalized treatment of lung cancer. The management of lung cancer and non–small cell lung cancer particularly is influenced by discoveries of activating mutations in epidermal growth factor receptor and targeted therapies with tyrosine kinase inhibitors, fusion genes involving anaplastic lymphoma kinase, and targeted therapies for Kristen-Rat-Sarcoma and MET protooncogenes. PET imaging plays an important role in assessing the biologic behavior of lung cancer and defining response to therapy. This review summarizes genomic discoveries in lung cancer and their implications for functional PET imaging.

Original languageEnglish (US)
Pages (from-to)243-259
Number of pages17
JournalPET Clinics
Volume11
Issue number3
DOIs
StatePublished - Jul 1 2016

Keywords

  • Genomics
  • Lung cancer
  • Management
  • PET/CT imaging
  • Personalized medicine

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging

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