The Current and Evolving Role of PET in Personalized Management of Lung Cancer

Esther Mena; Anusha Yanamadala; Gang Cheng; Rathan M. Subramaniam

doi:10.1016/j.cpet.2016.02.010

The Current and Evolving Role of PET in Personalized Management of Lung Cancer

Esther Mena, Anusha Yanamadala, Gang Cheng, Rathan M. Subramaniam

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Using tumor genomic profiling information has revolutionized the landscape of personalized treatment of lung cancer. The management of lung cancer and non–small cell lung cancer particularly is influenced by discoveries of activating mutations in epidermal growth factor receptor and targeted therapies with tyrosine kinase inhibitors, fusion genes involving anaplastic lymphoma kinase, and targeted therapies for Kristen-Rat-Sarcoma and MET protooncogenes. PET imaging plays an important role in assessing the biologic behavior of lung cancer and defining response to therapy. This review summarizes genomic discoveries in lung cancer and their implications for functional PET imaging.

Original language	English (US)
Pages (from-to)	243-259
Number of pages	17
Journal	PET Clinics
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/j.cpet.2016.02.010
State	Published - Jul 1 2016

Keywords

Genomics
Lung cancer
Management
PET/CT imaging
Personalized medicine

ASJC Scopus subject areas

Radiation
Radiology Nuclear Medicine and imaging

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10.1016/j.cpet.2016.02.010

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title = "The Current and Evolving Role of PET in Personalized Management of Lung Cancer",

abstract = "Using tumor genomic profiling information has revolutionized the landscape of personalized treatment of lung cancer. The management of lung cancer and non–small cell lung cancer particularly is influenced by discoveries of activating mutations in epidermal growth factor receptor and targeted therapies with tyrosine kinase inhibitors, fusion genes involving anaplastic lymphoma kinase, and targeted therapies for Kristen-Rat-Sarcoma and MET protooncogenes. PET imaging plays an important role in assessing the biologic behavior of lung cancer and defining response to therapy. This review summarizes genomic discoveries in lung cancer and their implications for functional PET imaging.",

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AU - Mena, Esther

AU - Yanamadala, Anusha

AU - Cheng, Gang

AU - Subramaniam, Rathan M.

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N2 - Using tumor genomic profiling information has revolutionized the landscape of personalized treatment of lung cancer. The management of lung cancer and non–small cell lung cancer particularly is influenced by discoveries of activating mutations in epidermal growth factor receptor and targeted therapies with tyrosine kinase inhibitors, fusion genes involving anaplastic lymphoma kinase, and targeted therapies for Kristen-Rat-Sarcoma and MET protooncogenes. PET imaging plays an important role in assessing the biologic behavior of lung cancer and defining response to therapy. This review summarizes genomic discoveries in lung cancer and their implications for functional PET imaging.

AB - Using tumor genomic profiling information has revolutionized the landscape of personalized treatment of lung cancer. The management of lung cancer and non–small cell lung cancer particularly is influenced by discoveries of activating mutations in epidermal growth factor receptor and targeted therapies with tyrosine kinase inhibitors, fusion genes involving anaplastic lymphoma kinase, and targeted therapies for Kristen-Rat-Sarcoma and MET protooncogenes. PET imaging plays an important role in assessing the biologic behavior of lung cancer and defining response to therapy. This review summarizes genomic discoveries in lung cancer and their implications for functional PET imaging.

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KW - Lung cancer

KW - Management

KW - PET/CT imaging

KW - Personalized medicine

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The Current and Evolving Role of PET in Personalized Management of Lung Cancer

Abstract

Keywords

ASJC Scopus subject areas

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