TY - JOUR
T1 - The current approach to the diagnosis of myelodysplastic syndromes☆
AU - Weinberg, Olga K.
AU - Hasserjian, Robert P.
N1 - Publisher Copyright:
© 2018
PY - 2019/1
Y1 - 2019/1
N2 - Myelodysplastic syndromes (MDS) are heterogeneous hematopoietic neoplasms that share key clinical and biologic features, including peripheral blood cytopenias, morphologic dysplasia, ineffective and clonal hematopoiesis, and a variable risk of transformation to acute myeloid leukemia. Diagnostic evaluation of MDS relies on morphologic assessment of the peripheral blood and bone marrow, conventional cytogenetics, and exclusion of secondary causes of dysplasia. The diagnosis of MDS has important clinical consequences, but it can be challenging and requires distinction from mimics. In this review, the principles of bone marrow interpretation with respect to the diagnosis and classification of MDS in the current era will be discussed, including accurate morphologic interpretation, use of flow cytometry and immunohistochemistry, appropriate use of cytogenetics, and the emerging role of molecular genetics.
AB - Myelodysplastic syndromes (MDS) are heterogeneous hematopoietic neoplasms that share key clinical and biologic features, including peripheral blood cytopenias, morphologic dysplasia, ineffective and clonal hematopoiesis, and a variable risk of transformation to acute myeloid leukemia. Diagnostic evaluation of MDS relies on morphologic assessment of the peripheral blood and bone marrow, conventional cytogenetics, and exclusion of secondary causes of dysplasia. The diagnosis of MDS has important clinical consequences, but it can be challenging and requires distinction from mimics. In this review, the principles of bone marrow interpretation with respect to the diagnosis and classification of MDS in the current era will be discussed, including accurate morphologic interpretation, use of flow cytometry and immunohistochemistry, appropriate use of cytogenetics, and the emerging role of molecular genetics.
KW - Cytogenetic findings
KW - Diagnosis
KW - Etiology
KW - Mutations
KW - Myelodysplastic syndrome
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=85049464196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049464196&partnerID=8YFLogxK
U2 - 10.1053/j.seminhematol.2018.05.015
DO - 10.1053/j.seminhematol.2018.05.015
M3 - Review article
C2 - 30573039
AN - SCOPUS:85049464196
SN - 0037-1963
VL - 56
SP - 15
EP - 21
JO - Seminars in hematology
JF - Seminars in hematology
IS - 1
ER -