The current state of tissue engineering in the management of hypospadias

Yvonne Y. Chan, Matthew I. Bury, Emily M. Yura, Matthias D. Hofer, Earl Y. Cheng, Arun K. Sharma

Research output: Contribution to journalReview articlepeer-review

Abstract

Hypospadias is a congenital malformation resulting from the disruption of normal urethral formation with varying global prevalence. Hypospadias repair, especially that of proximal hypospadias (in which reconstruction of a long urethra is necessary), remains a surgical challenge despite more than two decades of surgical technique development and refinement. The lack of tissue substitutes with mechanical and biological properties similar to those of native urethra is a challenge for which the field of tissue engineering might offer promising solutions. However, the use of tissue-engineered constructs in preclinical studies is still hindered by complications such as strictures or fistulae, which have slowed progression to clinical application. Furthermore, the generation of uniform tubular constructs remains a challenge. Exciting advances in the application of nanotechnology and 3D bioprinting to urethral tissue engineering might present solutions to these issues.

Original languageEnglish (US)
Pages (from-to)162-175
Number of pages14
JournalNature Reviews Urology
Volume17
Issue number3
DOIs
StatePublished - Mar 1 2020
Externally publishedYes

ASJC Scopus subject areas

  • Urology

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