The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension

Norman M Kaplan

Research output: Contribution to journalReview article

1418 Scopus citations

Abstract

The contribution of obesity to cardiovascular risk has not been adequately appreciated because of a failure to recognize the involvement of upper-body predominance of body weight with hypertension, diabetes, and hypertriglyceridemia even in the absence of significant overall obesity. This article examines the evidence that upper-body obesity, as usually induced by caloric excess in the presence of androgens, mediates these problems by way of hyperinsulinemia. Because of these interrelationships, there is a need to identify and prevent upper-body obesity or, failing that, to provide therapies that will control the associated problems without aggravating hyperinsulinemia.

Original languageEnglish (US)
Pages (from-to)1514-1520
Number of pages7
JournalArchives of Internal Medicine
Volume149
Issue number7
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Internal Medicine

Fingerprint Dive into the research topics of 'The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension'. Together they form a unique fingerprint.

  • Cite this