The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension

Norman M Kaplan

Research output: Contribution to journalArticle

1397 Citations (Scopus)

Abstract

The contribution of obesity to cardiovascular risk has not been adequately appreciated because of a failure to recognize the involvement of upper-body predominance of body weight with hypertension, diabetes, and hypertriglyceridemia even in the absence of significant overall obesity. This article examines the evidence that upper-body obesity, as usually induced by caloric excess in the presence of androgens, mediates these problems by way of hyperinsulinemia. Because of these interrelationships, there is a need to identify and prevent upper-body obesity or, failing that, to provide therapies that will control the associated problems without aggravating hyperinsulinemia.

Original languageEnglish (US)
Pages (from-to)1514-1520
Number of pages7
JournalArchives of Internal Medicine
Volume149
Issue number7
StatePublished - 1989

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Glucose Intolerance
Hypertriglyceridemia
Obesity
Hypertension
Hyperinsulinism
Androgens
Body Weight
Therapeutics

ASJC Scopus subject areas

  • Internal Medicine

Cite this

The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. / Kaplan, Norman M.

In: Archives of Internal Medicine, Vol. 149, No. 7, 1989, p. 1514-1520.

Research output: Contribution to journalArticle

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