TY - JOUR
T1 - The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension
AU - Kaplan, Norman M
PY - 1989/1/1
Y1 - 1989/1/1
N2 - The contribution of obesity to cardiovascular risk has not been adequately appreciated because of a failure to recognize the involvement of upper-body predominance of body weight with hypertension, diabetes, and hypertriglyceridemia even in the absence of significant overall obesity. This article examines the evidence that upper-body obesity, as usually induced by caloric excess in the presence of androgens, mediates these problems by way of hyperinsulinemia. Because of these interrelationships, there is a need to identify and prevent upper-body obesity or, failing that, to provide therapies that will control the associated problems without aggravating hyperinsulinemia.
AB - The contribution of obesity to cardiovascular risk has not been adequately appreciated because of a failure to recognize the involvement of upper-body predominance of body weight with hypertension, diabetes, and hypertriglyceridemia even in the absence of significant overall obesity. This article examines the evidence that upper-body obesity, as usually induced by caloric excess in the presence of androgens, mediates these problems by way of hyperinsulinemia. Because of these interrelationships, there is a need to identify and prevent upper-body obesity or, failing that, to provide therapies that will control the associated problems without aggravating hyperinsulinemia.
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U2 - 10.1001/archinte.149.7.1514
DO - 10.1001/archinte.149.7.1514
M3 - Review article
C2 - 2662932
AN - SCOPUS:0024391834
SN - 0003-9926
VL - 149
SP - 1514
EP - 1520
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 7
ER -