The developmental origins of adipose tissue

Daniel C. Berry, Drew Stenesen, Daniel Zeve, Jonathan M. Graff

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Adipose tissue is formed at stereotypic times and locations in a diverse array of organisms. Once formed, the tissue is dynamic, responding to homeostatic and external cues and capable of a 15-fold expansion. The formation and maintenance of adipose tissue is essential to many biological processes and when perturbed leads to significant diseases. Despite this basic and clinical significance, understanding of the developmental biology of adipose tissue has languished. In this Review, we highlight recent efforts to unveil adipose developmental cues, adipose stem cell biology and the regulators of adipose tissue homeostasis and dynamism.

Original languageEnglish (US)
Pages (from-to)3939-3949
Number of pages11
JournalDevelopment (Cambridge)
Volume140
Issue number19
DOIs
StatePublished - Oct 1 2013

Fingerprint

Adipose Tissue
Cues
Biological Phenomena
Developmental Biology
Cell Biology
Homeostasis
Stem Cells
Maintenance

Keywords

  • Adipocyte
  • Adipose
  • Development
  • Niche
  • Stem cells
  • Vascular niche

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology

Cite this

The developmental origins of adipose tissue. / Berry, Daniel C.; Stenesen, Drew; Zeve, Daniel; Graff, Jonathan M.

In: Development (Cambridge), Vol. 140, No. 19, 01.10.2013, p. 3939-3949.

Research output: Contribution to journalArticle

Berry, DC, Stenesen, D, Zeve, D & Graff, JM 2013, 'The developmental origins of adipose tissue', Development (Cambridge), vol. 140, no. 19, pp. 3939-3949. https://doi.org/10.1242/dev.080549
Berry, Daniel C. ; Stenesen, Drew ; Zeve, Daniel ; Graff, Jonathan M. / The developmental origins of adipose tissue. In: Development (Cambridge). 2013 ; Vol. 140, No. 19. pp. 3939-3949.
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