The discovery that xeroderma pigmentosum (XP) results from defective nucleotide excision repair

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Most forms of the human hereditary disease xeroderma pigmentosum (XP) are due to a defect in nucleotide excision repair of DNA damage in skin cells associated with exposure to sunlight. This discovery by James Cleaver had an important impact on our understanding of nucleotide excision repair in mammals.

Original languageEnglish (US)
Pages (from-to)183-195
Number of pages13
JournalDNA repair
Volume3
Issue number2
DOIs
StatePublished - Feb 3 2004

Keywords

  • DNA repair
  • Hereditary diseases
  • History
  • Xeroderma pigmentosum

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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