Abstract
In a genetic screen for mutations that restrict cell growth and organ size, we identified a new tumor suppressor gene, dMST, which encodes the Drosophila homolog of the mammalian Ste20 kinase family members MST1 and MST2. Loss-of-function mutations in dMST result in overgrown tissues containing more cells of normal size. dMST mutant cells exhibit elevated levels of Cyclin E and DIAP1, increased cell growth and proliferation, and impaired apoptosis, dMST forms a complex with Sav and Wts, two tumor suppressors also implicated in regulating both cell proliferation and apoptosis, suggesting that they act in common pathways.
Original language | English (US) |
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Pages (from-to) | 2514-2519 |
Number of pages | 6 |
Journal | Genes and Development |
Volume | 17 |
Issue number | 20 |
DOIs | |
State | Published - Oct 15 2003 |
Keywords
- Apoptosis
- DMST
- MST1
- Sav
- Tumor suppressor
- Wts
ASJC Scopus subject areas
- Genetics
- Developmental Biology