The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis

Jianhang Jia, Wensheng Zhang, Bing Wang, Richard Trinko, Jin Jiang

Research output: Contribution to journalArticle

248 Citations (Scopus)

Abstract

In a genetic screen for mutations that restrict cell growth and organ size, we identified a new tumor suppressor gene, dMST, which encodes the Drosophila homolog of the mammalian Ste20 kinase family members MST1 and MST2. Loss-of-function mutations in dMST result in overgrown tissues containing more cells of normal size. dMST mutant cells exhibit elevated levels of Cyclin E and DIAP1, increased cell growth and proliferation, and impaired apoptosis, dMST forms a complex with Sav and Wts, two tumor suppressors also implicated in regulating both cell proliferation and apoptosis, suggesting that they act in common pathways.

Original languageEnglish (US)
Pages (from-to)2514-2519
Number of pages6
JournalGenes and Development
Volume17
Issue number20
DOIs
StatePublished - Oct 15 2003

Fingerprint

Cell Size
Drosophila
Phosphotransferases
Cell Proliferation
Apoptosis
Cyclin E
Mutation
Organ Size
Growth
Tumor Suppressor Genes
Neoplasms

Keywords

  • Apoptosis
  • DMST
  • MST1
  • Sav
  • Tumor suppressor
  • Wts

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. / Jia, Jianhang; Zhang, Wensheng; Wang, Bing; Trinko, Richard; Jiang, Jin.

In: Genes and Development, Vol. 17, No. 20, 15.10.2003, p. 2514-2519.

Research output: Contribution to journalArticle

Jia, Jianhang ; Zhang, Wensheng ; Wang, Bing ; Trinko, Richard ; Jiang, Jin. / The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. In: Genes and Development. 2003 ; Vol. 17, No. 20. pp. 2514-2519.
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